The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7
In the present work, four derivatives of salicylaldehyde (salicylaldehyde-hydrazone, phenylhydrazone, semicarbazone and thiosemicarbazone) were synthesized using both conventional (95% ethanol) and green (crude glycerol from biodiesel production) solvents. The obtained compounds were identified by e...
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| Format: | Article |
| Language: | English |
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Association of Chemical Engineers of Serbia
2017-01-01
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| Series: | Hemijska Industrija |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2017/0367-598X1700011K.pdf |
| _version_ | 1811265985263435776 |
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| author | Konstantinović Sandra S. Zlatković Milica Z. Ćirić Jovan T. Ilić Slavica B. Gojgić-Cvijović Gordana D. Veljković Vlada B. |
| author_facet | Konstantinović Sandra S. Zlatković Milica Z. Ćirić Jovan T. Ilić Slavica B. Gojgić-Cvijović Gordana D. Veljković Vlada B. |
| author_sort | Konstantinović Sandra S. |
| collection | DOAJ |
| description | In the present work, four derivatives of salicylaldehyde (salicylaldehyde-hydrazone, phenylhydrazone, semicarbazone and thiosemicarbazone) were synthesized using both conventional (95% ethanol) and green (crude glycerol from biodiesel production) solvents. The obtained compounds were identified by elemental microanalysis, as well as FTIR, UV/Vis and 1H-NMR spectroscopic methods. Yields of 93–98% of the compounds in crude glycerol were achieved within 10–25 min. The derivatives of salicylaldehyde and crude glycerol were used as a nitrogen and carbon source, respectively, in the medium for antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7. The highest concentrations of hexaene H-85 and azalomycine B were achieved in the medium containing salicylaldehyde-thiosemicarbazone (198 and 69 μg/cm3, respectively). Derivatives of salicylaldehyde also impacted the strain morphology. In the media with salicylaldehyde- phenylhydrazone and salicylaldehyde-thiosemicarbazone, S. hygroscopicus CH-7 grew like large dispersive pellets with long twisted filaments that produced the highest yield of the antibiotics. [Project of the Serbian Ministry of Education,
Science and Technological Development, Grant no. III 45001] |
| first_indexed | 2024-04-12T20:33:56Z |
| format | Article |
| id | doaj.art-7c004b33d08440a9b722786b8bd7dc19 |
| institution | Directory Open Access Journal |
| issn | 0367-598X 2217-7426 |
| language | English |
| last_indexed | 2024-04-12T20:33:56Z |
| publishDate | 2017-01-01 |
| publisher | Association of Chemical Engineers of Serbia |
| record_format | Article |
| series | Hemijska Industrija |
| spelling | doaj.art-7c004b33d08440a9b722786b8bd7dc192022-12-22T03:17:39ZengAssociation of Chemical Engineers of SerbiaHemijska Industrija0367-598X2217-74262017-01-0171648749410.2298/HEMIND170124011K0367-598X1700011KThe use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7Konstantinović Sandra S.0Zlatković Milica Z.1Ćirić Jovan T.2Ilić Slavica B.3Gojgić-Cvijović Gordana D.4Veljković Vlada B.5Faculty of Technology, LeskovacFaculty of Technology, LeskovacFaculty of Technology, LeskovacFaculty of Technology, LeskovacInstitute for Chemistry, Technology and Metalurgy, Department of Chemistry, BelgradeFaculty of Technology, LeskovacIn the present work, four derivatives of salicylaldehyde (salicylaldehyde-hydrazone, phenylhydrazone, semicarbazone and thiosemicarbazone) were synthesized using both conventional (95% ethanol) and green (crude glycerol from biodiesel production) solvents. The obtained compounds were identified by elemental microanalysis, as well as FTIR, UV/Vis and 1H-NMR spectroscopic methods. Yields of 93–98% of the compounds in crude glycerol were achieved within 10–25 min. The derivatives of salicylaldehyde and crude glycerol were used as a nitrogen and carbon source, respectively, in the medium for antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7. The highest concentrations of hexaene H-85 and azalomycine B were achieved in the medium containing salicylaldehyde-thiosemicarbazone (198 and 69 μg/cm3, respectively). Derivatives of salicylaldehyde also impacted the strain morphology. In the media with salicylaldehyde- phenylhydrazone and salicylaldehyde-thiosemicarbazone, S. hygroscopicus CH-7 grew like large dispersive pellets with long twisted filaments that produced the highest yield of the antibiotics. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III 45001]http://www.doiserbia.nb.rs/img/doi/0367-598X/2017/0367-598X1700011K.pdfglycerolsalicylaldehydeStreptomycesantibioticmorphology |
| spellingShingle | Konstantinović Sandra S. Zlatković Milica Z. Ćirić Jovan T. Ilić Slavica B. Gojgić-Cvijović Gordana D. Veljković Vlada B. The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7 Hemijska Industrija glycerol salicylaldehyde Streptomyces antibiotic morphology |
| title | The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7 |
| title_full | The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7 |
| title_fullStr | The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7 |
| title_full_unstemmed | The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7 |
| title_short | The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7 |
| title_sort | use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by streptomyces hygroscopicus ch 7 |
| topic | glycerol salicylaldehyde Streptomyces antibiotic morphology |
| url | http://www.doiserbia.nb.rs/img/doi/0367-598X/2017/0367-598X1700011K.pdf |
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