Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

KRAS is a small GTPase that regulates cell proliferation. Here, the authors show that a subset of cell surface glycosphingolipids regulate KRAS plasma membrane localization by modulating inner leaflet lipid composition, uncovering a requirement for KRAS oncogenesis that may have therapeutic potentia...

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Bibliographic Details
Main Authors: Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, Dina Montufar-Solis, Wei Chen, Maurice Wong, Yong Zhou, Carlito B. Lebrilla, John F. Hancock
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36128-5

Internet

https://doi.org/10.1038/s41467-023-36128-5

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