Retroperitoneal liposarcomas: the experience of a tertiary Asian center
<p>Abstract</p> <p>Background</p> <p>Liposarcoma is the single most common soft tissue sarcoma in the retroperitoneum.</p> <p>Materials and methods</p> <p>A retrospective review of patients with primary retroperitoneal liposarcoma treated between...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-02-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/9/1/12 |
| _version_ | 1818471536208642048 |
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| author | Chow Pierce Chew Min Teo Melissa Goh Brian Lee Ser Wong Wai Ooi London LPJ Soo Khee |
| author_facet | Chow Pierce Chew Min Teo Melissa Goh Brian Lee Ser Wong Wai Ooi London LPJ Soo Khee |
| author_sort | Chow Pierce |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Liposarcoma is the single most common soft tissue sarcoma in the retroperitoneum.</p> <p>Materials and methods</p> <p>A retrospective review of patients with primary retroperitoneal liposarcoma treated between June 1990 and June 2005 were conducted to evaluate the clinical results of resection for retroperitoneal liposarcomas (RPLS) and the prognostic factors for disease recurrence and patient survival in an Asian population.</p> <p>Results</p> <p>Twenty-one patients operated on for curative intent (12 Males, 9 Females; mean age: 52.4 years) were evaluated. Of these, 13 presented with tumors that were well differentiated (61.9%), 4 (19.0%) with myxoid/round cell, 3 (14.3%) with dedifferentiated and 1(4.8%) with pleomorphic morphology. The median tumor burden was 36 cm (9-83). Median follow-up time was 62 months. There was no peri-operative mortality and morbidity occurred in 6(28.6%) patients. Surgical margins were involved in 10(47.6%) patients. Resection of contiguous organs was required in 15(71.4%) to achieve gross surgical margins. Eleven out of the 21(52%) of the patients had recurrence of the tumor. Median disease-free survival was 19 months and the overall 3- and 5-year survival rate was 87% and 49% respectively.</p> <p>Conclusion</p> <p>An aggressive surgical approach in both primary and recurrent RPLS in our institution is associated with 3- and 5-year survival rate of 87% and 49% respectively. Contiguous organ resection is often required to achieve local control.</p> |
| first_indexed | 2024-04-14T03:52:32Z |
| format | Article |
| id | doaj.art-7c05d1537d76465cafca0d583abf7ae4 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-14T03:52:32Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-7c05d1537d76465cafca0d583abf7ae42022-12-22T02:13:57ZengBMCWorld Journal of Surgical Oncology1477-78192011-02-01911210.1186/1477-7819-9-12Retroperitoneal liposarcomas: the experience of a tertiary Asian centerChow PierceChew MinTeo MelissaGoh BrianLee SerWong WaiOoi London LPJSoo Khee<p>Abstract</p> <p>Background</p> <p>Liposarcoma is the single most common soft tissue sarcoma in the retroperitoneum.</p> <p>Materials and methods</p> <p>A retrospective review of patients with primary retroperitoneal liposarcoma treated between June 1990 and June 2005 were conducted to evaluate the clinical results of resection for retroperitoneal liposarcomas (RPLS) and the prognostic factors for disease recurrence and patient survival in an Asian population.</p> <p>Results</p> <p>Twenty-one patients operated on for curative intent (12 Males, 9 Females; mean age: 52.4 years) were evaluated. Of these, 13 presented with tumors that were well differentiated (61.9%), 4 (19.0%) with myxoid/round cell, 3 (14.3%) with dedifferentiated and 1(4.8%) with pleomorphic morphology. The median tumor burden was 36 cm (9-83). Median follow-up time was 62 months. There was no peri-operative mortality and morbidity occurred in 6(28.6%) patients. Surgical margins were involved in 10(47.6%) patients. Resection of contiguous organs was required in 15(71.4%) to achieve gross surgical margins. Eleven out of the 21(52%) of the patients had recurrence of the tumor. Median disease-free survival was 19 months and the overall 3- and 5-year survival rate was 87% and 49% respectively.</p> <p>Conclusion</p> <p>An aggressive surgical approach in both primary and recurrent RPLS in our institution is associated with 3- and 5-year survival rate of 87% and 49% respectively. Contiguous organ resection is often required to achieve local control.</p>http://www.wjso.com/content/9/1/12 |
| spellingShingle | Chow Pierce Chew Min Teo Melissa Goh Brian Lee Ser Wong Wai Ooi London LPJ Soo Khee Retroperitoneal liposarcomas: the experience of a tertiary Asian center World Journal of Surgical Oncology |
| title | Retroperitoneal liposarcomas: the experience of a tertiary Asian center |
| title_full | Retroperitoneal liposarcomas: the experience of a tertiary Asian center |
| title_fullStr | Retroperitoneal liposarcomas: the experience of a tertiary Asian center |
| title_full_unstemmed | Retroperitoneal liposarcomas: the experience of a tertiary Asian center |
| title_short | Retroperitoneal liposarcomas: the experience of a tertiary Asian center |
| title_sort | retroperitoneal liposarcomas the experience of a tertiary asian center |
| url | http://www.wjso.com/content/9/1/12 |
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