Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and HumansSummary

Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and HumansSummary

Background & Aims: Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in the pathogenesis of alcoholic pancreatiti...

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Bibliographic Details
Main Authors: Shaogui Wang, Hong-Min Ni, Xiaojuan Chao, Xiaowen Ma, Thomas Kolodecik, Robert De Lisle, Andrew Ballabio, Pal Pacher, Wen-Xing Ding
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Autophagy
Lysosome
Inflammation
Tissue Injury
Zymogen
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2030014X

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