Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i>
We report a fatal case of native valve endocarditis due to <i>Mycobacterium abscessus</i> in a hemodialysis patient. The diagnosis was based on culture isolation of acid-fast bacilli from peripheral blood and a permanent catheter tip, and their identification as <i>M abscessus</...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2010-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=408;epage=411;aulast=Al-Benwan |
| _version_ | 1819154927402876928 |
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| author | Al-Benwan Khalifa Ahmad Suhail Mokaddas Eiman Johny Molly Kapoor Madan |
| author_facet | Al-Benwan Khalifa Ahmad Suhail Mokaddas Eiman Johny Molly Kapoor Madan |
| author_sort | Al-Benwan Khalifa |
| collection | DOAJ |
| description | We report a fatal case of native valve endocarditis due to <i>Mycobacterium abscessus</i> in a hemodialysis patient. The diagnosis was based on culture isolation of acid-fast bacilli from peripheral blood and a permanent catheter tip, and their identification as <i>M abscessus</i> by a reverse hybridization-based assay and direct DNA sequencing of the 16S-23S internal transcribed spacer region. Rapid diagnosis and combination therapy are essential to minimize mortality due to this pathogen. Although combination therapy was started with clarithromycin and tigecycline, the patient refused to take clarithromycin due to severe abdominal pain. The patient became afebrile after therapy with tigecycline alone although bacteremia persisted. He was discharged against medical advice and readmitted three months later for persistent fever. His blood cultures again yielded <i>M abscessus</i> and a transesophageal echocardiogram showed two mobile vegetations. The patient was noncompliant with therapy and died due to cardiac arrest and multiorgan failure. This report shows that <i>M abscessus</i> should also be considered in the differential diagnosis of infective endocarditis in hemodialysis patients. |
| first_indexed | 2024-12-22T15:28:51Z |
| format | Article |
| id | doaj.art-7c06750c986c41aa9b6ce6018af92e67 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-22T15:28:51Z |
| publishDate | 2010-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-7c06750c986c41aa9b6ce6018af92e672022-12-21T18:21:24ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662010-01-01305408411Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i>Al-Benwan KhalifaAhmad SuhailMokaddas EimanJohny MollyKapoor MadanWe report a fatal case of native valve endocarditis due to <i>Mycobacterium abscessus</i> in a hemodialysis patient. The diagnosis was based on culture isolation of acid-fast bacilli from peripheral blood and a permanent catheter tip, and their identification as <i>M abscessus</i> by a reverse hybridization-based assay and direct DNA sequencing of the 16S-23S internal transcribed spacer region. Rapid diagnosis and combination therapy are essential to minimize mortality due to this pathogen. Although combination therapy was started with clarithromycin and tigecycline, the patient refused to take clarithromycin due to severe abdominal pain. The patient became afebrile after therapy with tigecycline alone although bacteremia persisted. He was discharged against medical advice and readmitted three months later for persistent fever. His blood cultures again yielded <i>M abscessus</i> and a transesophageal echocardiogram showed two mobile vegetations. The patient was noncompliant with therapy and died due to cardiac arrest and multiorgan failure. This report shows that <i>M abscessus</i> should also be considered in the differential diagnosis of infective endocarditis in hemodialysis patients.http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=408;epage=411;aulast=Al-Benwan |
| spellingShingle | Al-Benwan Khalifa Ahmad Suhail Mokaddas Eiman Johny Molly Kapoor Madan Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i> Annals of Saudi Medicine |
| title | Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i> |
| title_full | Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i> |
| title_fullStr | Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i> |
| title_full_unstemmed | Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i> |
| title_short | Diagnosis of endocarditis caused by <i>Mycobacterium abscessus</i> |
| title_sort | diagnosis of endocarditis caused by i mycobacterium abscessus i |
| url | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=408;epage=411;aulast=Al-Benwan |
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