γH2A/γH2AX Mediates DNA Damage-Specific Control of Checkpoint Signaling in <i>Saccharomyces cerevisiae</i>

γH2A/γH2AX Mediates DNA Damage-Specific Control of Checkpoint Signaling in <i>Saccharomyces cerevisiae</i>

DNA lesions trigger DNA damage checkpoint (DDC) signaling which arrests cell cycle progression and promotes DNA damage repair. In <i>Saccharomyces cerevisiae</i>, phosphorylation of histone H2A (γH2A, equivalent to γH2AX in mammals) is an early chromatin mark induced by DNA damage that i...

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Bibliographic Details
Main Authors: Jasmine Siler, Na Guo, Zhengfeng Liu, Yuhua Qin, Xin Bi
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
camptothecin
DNA damage checkpoint
γH2A/γH2AX
Rad9
Rad53
Online Access:https://www.mdpi.com/1422-0067/25/5/2462

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