Plasmodium translocon component EXP2 facilitates hepatocyte invasion
While the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19492-4 |
| _version_ | 1818994565098504192 |
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| author | João Mello-Vieira Francisco J. Enguita Tania F. de Koning-Ward Vanessa Zuzarte-Luís Maria M. Mota |
| author_facet | João Mello-Vieira Francisco J. Enguita Tania F. de Koning-Ward Vanessa Zuzarte-Luís Maria M. Mota |
| author_sort | João Mello-Vieira |
| collection | DOAJ |
| description | While the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepatocyte invasion. |
| first_indexed | 2024-12-20T20:59:58Z |
| format | Article |
| id | doaj.art-7c06f4db9999411dad1ae293d10c1e41 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:59:58Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7c06f4db9999411dad1ae293d10c1e412022-12-21T19:26:43ZengNature PortfolioNature Communications2041-17232020-11-0111111310.1038/s41467-020-19492-4Plasmodium translocon component EXP2 facilitates hepatocyte invasionJoão Mello-Vieira0Francisco J. Enguita1Tania F. de Koning-Ward2Vanessa Zuzarte-Luís3Maria M. Mota4Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaSchool of Medicine, Deakin University, Waurn PondsInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de LisboaWhile the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepatocyte invasion.https://doi.org/10.1038/s41467-020-19492-4 |
| spellingShingle | João Mello-Vieira Francisco J. Enguita Tania F. de Koning-Ward Vanessa Zuzarte-Luís Maria M. Mota Plasmodium translocon component EXP2 facilitates hepatocyte invasion Nature Communications |
| title | Plasmodium translocon component EXP2 facilitates hepatocyte invasion |
| title_full | Plasmodium translocon component EXP2 facilitates hepatocyte invasion |
| title_fullStr | Plasmodium translocon component EXP2 facilitates hepatocyte invasion |
| title_full_unstemmed | Plasmodium translocon component EXP2 facilitates hepatocyte invasion |
| title_short | Plasmodium translocon component EXP2 facilitates hepatocyte invasion |
| title_sort | plasmodium translocon component exp2 facilitates hepatocyte invasion |
| url | https://doi.org/10.1038/s41467-020-19492-4 |
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