Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence

Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence

Neurodegenerative diseases constitute a broad range of central nervous system disorders, characterized by neuronal degeneration. Alzheimer’s disease, Parkinson’s disease, amyolotrophic lateral sclerosis (ALS), and progressive forms of multiple sclerosis (MS) are some of the most frequent neurodegene...

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Bibliographic Details
Main Authors: Efthalia Angelopoulou, Efstratios-Stylianos Pyrgelis, Christina Piperi
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
ibudilast
PDE inhibitor
neurodegeneration
microglia
autophagy
lysosomes
Online Access:https://www.mdpi.com/1420-3049/27/23/8448

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