Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/full |
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| author | Pavel Hurník Pavel Hurník Zuzana Chyra Tereza Ševčíková Jan Štembírek Jan Štembírek Kateřina Smešný Trtková Kateřina Smešný Trtková Daria A. Gaykalova Daria A. Gaykalova Daria A. Gaykalova Daria A. Gaykalova Marcela Buchtová Marcela Buchtová Eva Hrubá Eva Hrubá |
| author_facet | Pavel Hurník Pavel Hurník Zuzana Chyra Tereza Ševčíková Jan Štembírek Jan Štembírek Kateřina Smešný Trtková Kateřina Smešný Trtková Daria A. Gaykalova Daria A. Gaykalova Daria A. Gaykalova Daria A. Gaykalova Marcela Buchtová Marcela Buchtová Eva Hrubá Eva Hrubá |
| author_sort | Pavel Hurník |
| collection | DOAJ |
| description | Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion’s extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors. |
| first_indexed | 2024-04-14T01:31:02Z |
| format | Article |
| id | doaj.art-7c08e8d0d1a54f2892d0a45881e22b4e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-14T01:31:02Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-7c08e8d0d1a54f2892d0a45881e22b4e2022-12-22T02:20:12ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.848557848557Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell CarcinomaPavel Hurník0Pavel Hurník1Zuzana Chyra2Tereza Ševčíková3Jan Štembírek4Jan Štembírek5Kateřina Smešný Trtková6Kateřina Smešný Trtková7Daria A. Gaykalova8Daria A. Gaykalova9Daria A. Gaykalova10Daria A. Gaykalova11Marcela Buchtová12Marcela Buchtová13Eva Hrubá14Eva Hrubá15Department of Clinical and Molecular Pathology and Medical Genetics, Faculty of Medicine and University Hospital Ostrava, Ostrava, CzechiaDepartment of Histology and Embryology, Medical Faculty, Masaryk University, Brno, CzechiaDepartment of Hematooncology, University Hospital Ostrava, Ostrava, CzechiaDepartment of Hematooncology, University Hospital Ostrava, Ostrava, CzechiaDepartment of Maxillofacial Surgery, University Hospital Ostrava, Ostrava, CzechiaLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, CzechiaDepartment of Clinical and Molecular Pathology and Medical Genetics, Faculty of Medicine and University Hospital Ostrava, Ostrava, CzechiaDepartment of Clinical and Molecular Pathology, Faculty of Medicine and University Hospital Olomouc, Olomouc, CzechiaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, United StatesInstitute for Genome Sciences, University of Maryland Medical Center, Baltimore, MD, United States0Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United StatesLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia1Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, CzechiaLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia1Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, CzechiaCarcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion’s extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/fullHNSCCperineural invasionepigeneticsoral cancermiRNAs |
| spellingShingle | Pavel Hurník Pavel Hurník Zuzana Chyra Tereza Ševčíková Jan Štembírek Jan Štembírek Kateřina Smešný Trtková Kateřina Smešný Trtková Daria A. Gaykalova Daria A. Gaykalova Daria A. Gaykalova Daria A. Gaykalova Marcela Buchtová Marcela Buchtová Eva Hrubá Eva Hrubá Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma Frontiers in Genetics HNSCC perineural invasion epigenetics oral cancer miRNAs |
| title | Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma |
| title_full | Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma |
| title_short | Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma |
| title_sort | epigenetic regulations of perineural invasion in head and neck squamous cell carcinoma |
| topic | HNSCC perineural invasion epigenetics oral cancer miRNAs |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/full |
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