An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in preclinical oral toxicity studies in rodents. Where...

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Bibliographic Details
Main Authors: Hannes Gierke, Kerstin Schaefer, Lukas Gerlich, Ann-Cathrin Willmann, Verena Bialetzki, Georg Boeck, Teresa Pfrommer, Thomas Nolte, Werner Weitschies
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
pharmacobezoars
in vitro model
spray dried amorphous solid dispersions
preclinical testing
rodent stomach
Online Access:https://www.mdpi.com/1999-4923/14/12/2608

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