Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis
Cystic echinococcosis (CE) is a cosmopolitan disease caused by the dog tapeworm Echinococcus granulosus. The disease is difficult to diagnose, treat, and control and is responsible for considerable human morbidity and mortality globally. There is an urgent need for new diagnostic tests and new drugs...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2014-01-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/parasite/2014066 |
| _version_ | 1797421468103999488 |
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| author | Zhang Wenbao Wang Shengyue McManus Donald P. |
| author_facet | Zhang Wenbao Wang Shengyue McManus Donald P. |
| author_sort | Zhang Wenbao |
| collection | DOAJ |
| description | Cystic echinococcosis (CE) is a cosmopolitan disease caused by the dog tapeworm Echinococcus granulosus. The disease is difficult to diagnose, treat, and control and is responsible for considerable human morbidity and mortality globally. There is an urgent need for new diagnostic tests and new drugs for treatment of CE and the development of a vaccine against adult worms of E. granulosus in dogs. We recently presented a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 proteins. We undertook an extensive comparative analysis of the E. granulosus transcriptome using representative life stages (protoscoleces, cyst germinal cells and membranes, adult worms, and oncospheres) to explore different aspects of tapeworm biology and parasitism. The genome and transcriptome of E. granulosus provide a unique platform for post-genomic research and to facilitate the development of new, effective treatments and interventions for echinococcosis control. |
| first_indexed | 2024-03-09T07:17:56Z |
| format | Article |
| id | doaj.art-7c09e7517eb247f2b502004976c0aeac |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T07:17:56Z |
| publishDate | 2014-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-7c09e7517eb247f2b502004976c0aeac2023-12-03T08:19:39ZengEDP SciencesParasite1776-10422014-01-01216610.1051/parasite/2014066parasite140086Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosisZhang WenbaoWang ShengyueMcManus Donald P.Cystic echinococcosis (CE) is a cosmopolitan disease caused by the dog tapeworm Echinococcus granulosus. The disease is difficult to diagnose, treat, and control and is responsible for considerable human morbidity and mortality globally. There is an urgent need for new diagnostic tests and new drugs for treatment of CE and the development of a vaccine against adult worms of E. granulosus in dogs. We recently presented a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 proteins. We undertook an extensive comparative analysis of the E. granulosus transcriptome using representative life stages (protoscoleces, cyst germinal cells and membranes, adult worms, and oncospheres) to explore different aspects of tapeworm biology and parasitism. The genome and transcriptome of E. granulosus provide a unique platform for post-genomic research and to facilitate the development of new, effective treatments and interventions for echinococcosis control.http://dx.doi.org/10.1051/parasite/2014066Echinococcus granulosusCystic echinococcosisCestodesGenomicsDrug designZoonosis control |
| spellingShingle | Zhang Wenbao Wang Shengyue McManus Donald P. Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis Parasite Echinococcus granulosus Cystic echinococcosis Cestodes Genomics Drug design Zoonosis control |
| title | Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis |
| title_full | Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis |
| title_fullStr | Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis |
| title_full_unstemmed | Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis |
| title_short | Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis |
| title_sort | echinococcus granulosus genomics a new dawn for improved diagnosis treatment and control of echinococcosis |
| topic | Echinococcus granulosus Cystic echinococcosis Cestodes Genomics Drug design Zoonosis control |
| url | http://dx.doi.org/10.1051/parasite/2014066 |
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