Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii
It is quite difficult to diagnose active toxoplasmosis in patients with ocular toxoplasmosis. Active posterior uveitis presumably due to Toxoplasma gondii infection (APUPT) is seldom produced during a prime-infection; hence most patients do not show high IgM antibodies. High levels of IgA have been...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000800013 |
| _version_ | 1797718367118819328 |
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| author | Maria Isabel Lynch Francisco Cordeiro Silvana Ferreira Ricardo Ximenes Fernando Oréfice Elizabeth Malagueño |
| author_facet | Maria Isabel Lynch Francisco Cordeiro Silvana Ferreira Ricardo Ximenes Fernando Oréfice Elizabeth Malagueño |
| author_sort | Maria Isabel Lynch |
| collection | DOAJ |
| description | It is quite difficult to diagnose active toxoplasmosis in patients with ocular toxoplasmosis. Active posterior uveitis presumably due to Toxoplasma gondii infection (APUPT) is seldom produced during a prime-infection; hence most patients do not show high IgM antibodies. High levels of IgA have been described in active toxoplasmosis. The purpose of this study was to investigate possible association between APUPT and the specific anti-parasite sIgA in tears. The study was carried out as case-control. Tears of 25 clinically confirmed APUPT patients and 50 healthy control subjects were analyzed. All were IgG seropositive. Specific sIgA was determined by ELISA assay using T. gondii RH strain crude extract. Anti-T. gondii sIgA was found in 84% of the cases and in 22% of the control subjects. The intensity of the reaction was higher in APUPT cases (P = 0.007). There was strong association between APUPT patients and lacrimal sIgA (odds-ratio 18.61, P = 0.0001). ELISA test sensitivity was 84% and specificity 78% . Our data suggest that anti-T.gondii secretory IgA found in tears may become an important marker for active ocular toxoplasmosis. |
| first_indexed | 2024-03-12T08:49:59Z |
| format | Article |
| id | doaj.art-7c0a969f301a42a0932223e32d363ed1 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:49:59Z |
| publishDate | 2004-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-7c0a969f301a42a0932223e32d363ed12023-09-02T16:21:41ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-12-0199886186410.1590/S0074-02762004000800013Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondiiMaria Isabel LynchFrancisco CordeiroSilvana FerreiraRicardo XimenesFernando OréficeElizabeth MalagueñoIt is quite difficult to diagnose active toxoplasmosis in patients with ocular toxoplasmosis. Active posterior uveitis presumably due to Toxoplasma gondii infection (APUPT) is seldom produced during a prime-infection; hence most patients do not show high IgM antibodies. High levels of IgA have been described in active toxoplasmosis. The purpose of this study was to investigate possible association between APUPT and the specific anti-parasite sIgA in tears. The study was carried out as case-control. Tears of 25 clinically confirmed APUPT patients and 50 healthy control subjects were analyzed. All were IgG seropositive. Specific sIgA was determined by ELISA assay using T. gondii RH strain crude extract. Anti-T. gondii sIgA was found in 84% of the cases and in 22% of the control subjects. The intensity of the reaction was higher in APUPT cases (P = 0.007). There was strong association between APUPT patients and lacrimal sIgA (odds-ratio 18.61, P = 0.0001). ELISA test sensitivity was 84% and specificity 78% . Our data suggest that anti-T.gondii secretory IgA found in tears may become an important marker for active ocular toxoplasmosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000800013anti-Toxoplasma gondii secretory IgAocular toxoplasmosis diagnosisantibodies anti-T. gondiisecretory IgA and ocular toxoplasmosis |
| spellingShingle | Maria Isabel Lynch Francisco Cordeiro Silvana Ferreira Ricardo Ximenes Fernando Oréfice Elizabeth Malagueño Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii Memorias do Instituto Oswaldo Cruz anti-Toxoplasma gondii secretory IgA ocular toxoplasmosis diagnosis antibodies anti-T. gondii secretory IgA and ocular toxoplasmosis |
| title | Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii |
| title_full | Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii |
| title_fullStr | Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii |
| title_full_unstemmed | Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii |
| title_short | Lacrimal secretory IgA in active posterior uveitis induced by Toxoplasma gondii |
| title_sort | lacrimal secretory iga in active posterior uveitis induced by toxoplasma gondii |
| topic | anti-Toxoplasma gondii secretory IgA ocular toxoplasmosis diagnosis antibodies anti-T. gondii secretory IgA and ocular toxoplasmosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000800013 |
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