Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation

Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation

Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections with Candida of the skin, nails, and mucous membranes (e.g., mouth, esophagus, and vagina). Compared with that of other infectious diseases, the immune pathogenic mechanism of CMC is still poorly understoo...

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Bibliographic Details
Main Authors: Xiaodi Lu, Keming Zhang, Weiwei Jiang, Hang Li, Yue Huang, Mingwei Du, Jian Wan, Yanyun Cao, Lin Du, Xiaogang Liu, Weihua Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
chronic mucocutaneous candidiasis (CMC)
signal transducer and activator of transcription 1 (STAT1)
heterozygous mutation
single-cell RNA sequencing (scRNAseq)
immune mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.988766/full

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