Molecular responses to hypoxia in tumor cells
<p>Abstract</p> <p>Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology. Among these are activ...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2003-04-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://www.molecular-cancer.com/content/2/1/23 |
| _version_ | 1818117040181870592 |
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| author | Ibrahim Saleh M Kunz Manfred |
| author_facet | Ibrahim Saleh M Kunz Manfred |
| author_sort | Ibrahim Saleh M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology. Among these are activation of certain signal transduction pathways and gene regulatory mechanisms, induction of selection processes for gene mutations, tumor cell apoptosis and tumor angiogenesis. Most of these mechanisms contribute to tumor progression. Therefore, tissue hypoxia has been regarded as a central factor for tumor aggressiveness and metastasis. In this review, we summarize the current knowledge about the molecular mechanisms induced by tumor cell hypoxia with a special emphasis on intracellular signal transduction, gene regulation, angiogenesis and apoptosis. Interfering with these pathways might open perspectives for future innovative treatment of highly aggressive metastasizing tumors.</p> |
| first_indexed | 2024-12-11T04:32:05Z |
| format | Article |
| id | doaj.art-7c0b9d144d8f46ed93c88407b43780d1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-11T04:32:05Z |
| publishDate | 2003-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-7c0b9d144d8f46ed93c88407b43780d12022-12-22T01:20:49ZengBMCMolecular Cancer1476-45982003-04-01212310.1186/1476-4598-2-23Molecular responses to hypoxia in tumor cellsIbrahim Saleh MKunz Manfred<p>Abstract</p> <p>Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology. Among these are activation of certain signal transduction pathways and gene regulatory mechanisms, induction of selection processes for gene mutations, tumor cell apoptosis and tumor angiogenesis. Most of these mechanisms contribute to tumor progression. Therefore, tissue hypoxia has been regarded as a central factor for tumor aggressiveness and metastasis. In this review, we summarize the current knowledge about the molecular mechanisms induced by tumor cell hypoxia with a special emphasis on intracellular signal transduction, gene regulation, angiogenesis and apoptosis. Interfering with these pathways might open perspectives for future innovative treatment of highly aggressive metastasizing tumors.</p>http://www.molecular-cancer.com/content/2/1/23Hypoxiagene regulationsignal transductionangiogenesisapoptosis |
| spellingShingle | Ibrahim Saleh M Kunz Manfred Molecular responses to hypoxia in tumor cells Molecular Cancer Hypoxia gene regulation signal transduction angiogenesis apoptosis |
| title | Molecular responses to hypoxia in tumor cells |
| title_full | Molecular responses to hypoxia in tumor cells |
| title_fullStr | Molecular responses to hypoxia in tumor cells |
| title_full_unstemmed | Molecular responses to hypoxia in tumor cells |
| title_short | Molecular responses to hypoxia in tumor cells |
| title_sort | molecular responses to hypoxia in tumor cells |
| topic | Hypoxia gene regulation signal transduction angiogenesis apoptosis |
| url | http://www.molecular-cancer.com/content/2/1/23 |
| work_keys_str_mv | AT ibrahimsalehm molecularresponsestohypoxiaintumorcells AT kunzmanfred molecularresponsestohypoxiaintumorcells |