Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group
Objectives: Bowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution NiflecⓇ (Nif). MoviPrep (Mov)Ⓡ is a hyperosmolar preparation of PEG, electrolytes, and ascorbic acid; despite the smaller dose volume of 2 L, i...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Japan Society of Coloproctology
2024-01-01
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| Series: | Journal of the Anus, Rectum and Colon |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jarc/8/1/8_2023-030/_pdf/-char/en |
| _version_ | 1797346871109222400 |
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| author | Naoki Asayama Shiro Oka Shinji Nagata Taiji Matsuo Taiki Aoyama Toru Kawamura Tsuyoshi Kuroda Yuko Hiraga Koichi Nakadoi Masaki Kunihiro Mayu Ohnishi Shinji Tanaka |
| author_facet | Naoki Asayama Shiro Oka Shinji Nagata Taiji Matsuo Taiki Aoyama Toru Kawamura Tsuyoshi Kuroda Yuko Hiraga Koichi Nakadoi Masaki Kunihiro Mayu Ohnishi Shinji Tanaka |
| author_sort | Naoki Asayama |
| collection | DOAJ |
| description | Objectives: Bowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution NiflecⓇ (Nif). MoviPrep (Mov)Ⓡ is a hyperosmolar preparation of PEG, electrolytes, and ascorbic acid; despite the smaller dose volume of 2 L, it can be challenging for many patients. We examined a more effective and acceptable bowel preparation method without compromising cleanliness and effectiveness, combining low-residue diet and laxative (Modified Brown Method) in Mov administered 1 day pre-colonoscopy.
Methods: This multicenter, randomized, open-label, parallel-group comparative study, conducted at Hiroshima University Hospital and 7 affiliated hospitals in May 2015-March 2016, evaluated adherence to and effectiveness of Mov in bowel preparation. Participants (n=380) were allocated to receive 1 of 3 pre-colonoscopy regimens: Nif+Modified Brown Method (Group A), Mov+Modified Brown Method (Group B), or Mov+Laxative (Group C).
Results: Total intake volume showed no significant difference among the groups. Bowel preparation time was significantly shorter in Group B (112.4±44.8 min, n=118) than in Groups A (131.3±59 min, n=105) and C (122.6±48.1 min, n=115). Sleep disturbance (37%) was significantly higher in Group B than Group A; distension (11%) was significantly lower in Group C than in Groups A and B (p<0.05, respectively). No severe adverse events occurred in any group.
Conclusions: Mov+Modified Brown method provided significantly shorter bowel preparation time, with no significant difference in total intake volume among the regimens. Mov+Laxative yielded significantly less distension than the other groups, with bowel preparation equivalent to that of the Nif+Modified Brown method. |
| first_indexed | 2024-03-08T11:39:28Z |
| format | Article |
| id | doaj.art-7c0c5ef6dd56414bb9d56e3f22372606 |
| institution | Directory Open Access Journal |
| issn | 2432-3853 |
| language | English |
| last_indexed | 2024-03-08T11:39:28Z |
| publishDate | 2024-01-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj.art-7c0c5ef6dd56414bb9d56e3f223726062024-01-25T07:45:34ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532024-01-018191710.23922/jarc.2023-0302023-030Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research GroupNaoki Asayama0Shiro Oka1Shinji Nagata2Taiji Matsuo3Taiki Aoyama4Toru Kawamura5Tsuyoshi Kuroda6Yuko Hiraga7Koichi Nakadoi8Masaki Kunihiro9Mayu Ohnishi10Shinji Tanaka11Department of Gastroenterology, Hiroshima City North Medical Center Asa Citizens HospitalDepartment of Gastroenterology, Hiroshima University HospitalDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens HospitalDepartment of Endoscopy, Hiroshima University HospitalDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens HospitalKawamura ClinicDepartment of Gastroenterology, Mazda HospitalDepartment of Endoscopy, Hiroshima Prefectural HospitalDepartment of Gastroenterology, Onomichi General HospitalDepartment of Internal Medicine, Hiroshima City Hiroshima Citizens HospitalDepartment of Gastroenterology, Miyoshi Medical Association HospitalDepartment of Endoscopy, Hiroshima University HospitalObjectives: Bowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution NiflecⓇ (Nif). MoviPrep (Mov)Ⓡ is a hyperosmolar preparation of PEG, electrolytes, and ascorbic acid; despite the smaller dose volume of 2 L, it can be challenging for many patients. We examined a more effective and acceptable bowel preparation method without compromising cleanliness and effectiveness, combining low-residue diet and laxative (Modified Brown Method) in Mov administered 1 day pre-colonoscopy. Methods: This multicenter, randomized, open-label, parallel-group comparative study, conducted at Hiroshima University Hospital and 7 affiliated hospitals in May 2015-March 2016, evaluated adherence to and effectiveness of Mov in bowel preparation. Participants (n=380) were allocated to receive 1 of 3 pre-colonoscopy regimens: Nif+Modified Brown Method (Group A), Mov+Modified Brown Method (Group B), or Mov+Laxative (Group C). Results: Total intake volume showed no significant difference among the groups. Bowel preparation time was significantly shorter in Group B (112.4±44.8 min, n=118) than in Groups A (131.3±59 min, n=105) and C (122.6±48.1 min, n=115). Sleep disturbance (37%) was significantly higher in Group B than Group A; distension (11%) was significantly lower in Group C than in Groups A and B (p<0.05, respectively). No severe adverse events occurred in any group. Conclusions: Mov+Modified Brown method provided significantly shorter bowel preparation time, with no significant difference in total intake volume among the regimens. Mov+Laxative yielded significantly less distension than the other groups, with bowel preparation equivalent to that of the Nif+Modified Brown method.https://www.jstage.jst.go.jp/article/jarc/8/1/8_2023-030/_pdf/-char/encolonoscopybowel preparationmoviprepⓡmodified brown method |
| spellingShingle | Naoki Asayama Shiro Oka Shinji Nagata Taiji Matsuo Taiki Aoyama Toru Kawamura Tsuyoshi Kuroda Yuko Hiraga Koichi Nakadoi Masaki Kunihiro Mayu Ohnishi Shinji Tanaka Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group Journal of the Anus, Rectum and Colon colonoscopy bowel preparation moviprepⓡ modified brown method |
| title | Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group |
| title_full | Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group |
| title_fullStr | Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group |
| title_full_unstemmed | Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group |
| title_short | Adherence and Effectiveness of MoviPrepⓇ in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group |
| title_sort | adherence and effectiveness of moviprepⓡ in bowel preparation for colonoscopy a multicenter study from the hiroshima gi endoscopy research group |
| topic | colonoscopy bowel preparation moviprepⓡ modified brown method |
| url | https://www.jstage.jst.go.jp/article/jarc/8/1/8_2023-030/_pdf/-char/en |
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