Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs

Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs

Summary: The catalytic role of U6 snRNP in pre-mRNA splicing has been well established. In this study, we utilize an antisense morpholino oligonucleotide (AMO) specifically targeting catalytic sites of U6 snRNA to achieve functional knockdown of U6 snRNP in HeLa cells. The data show a significant in...

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Bibliographic Details
Main Authors: Qiumin Feng, Zejin Lin, Danhui Zhao, Mengzhao Li, Sheng Yang, Andy Peng Xiang, Congting Ye, Chengguo Yao
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725001470

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http://www.sciencedirect.com/science/article/pii/S2211124725001470

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