Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson’s Disease Differently Affects Behavior

Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson’s Disease Differently Affects Behavior

Parkinson’s disease (PD) is one of the most frequent neurodegenerative disorders. The loss of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic interneurons in the striatum. Pharmacotherapeutical strategies of PD-related hypercholinism have numerous adverse side ef...

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Bibliographic Details
Main Authors: Veronica A. Antipova, Carsten Holzmann, Oliver Schmitt, Andreas Wree, Alexander Hawlitschka
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
botulinum toxins
hemiparkinsonism
behavior
Wistar rats
striatum
Online Access:http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00119/full

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