Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model
Peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain and projecting to the nucleus accumbens (NAc) of the striatum. We have pr...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14147 |
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| author | Gavin C. Jones Christina A. Small Dallin Z. Otteson Caylor W. Hafen Jacob T. Breinholt Paul D. Flora Matthew D. Burris David W. Sant Tysum R. Ruchti Jordan T. Yorgason Scott C. Steffensen Kyle B. Bills |
| author_facet | Gavin C. Jones Christina A. Small Dallin Z. Otteson Caylor W. Hafen Jacob T. Breinholt Paul D. Flora Matthew D. Burris David W. Sant Tysum R. Ruchti Jordan T. Yorgason Scott C. Steffensen Kyle B. Bills |
| author_sort | Gavin C. Jones |
| collection | DOAJ |
| description | Peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain and projecting to the nucleus accumbens (NAc) of the striatum. We have previously shown that mechanoreceptor activation via whole-body vibration (WBV) ameliorates neuronal and behavioral effects of chronic ethanol exposure. In this study, we employ a similar paradigm to assess the efficacy of WBV as a preventative measure of neuronal and behavioral effects of morphine withdrawal in a Wistar rat model. We demonstrate that concurrent administration of WBV at 80 Hz with morphine over a 5-day period significantly reduced adaptations in VTA GABA neuronal activity and NAc DA release and modulated expression of δ-opioid receptors (DORs) on NAc cholinergic interneurons (CINs) during withdrawal. We also observed a reduction in behavior typically associated with opioid withdrawal. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD) and should be examined translationally in humans. |
| first_indexed | 2024-03-10T22:39:14Z |
| format | Article |
| id | doaj.art-7c0ca2f7887f414699d096345e68669a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:14Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7c0ca2f7887f414699d096345e68669a2023-11-19T11:08:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181414710.3390/ijms241814147Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat ModelGavin C. Jones0Christina A. Small1Dallin Z. Otteson2Caylor W. Hafen3Jacob T. Breinholt4Paul D. Flora5Matthew D. Burris6David W. Sant7Tysum R. Ruchti8Jordan T. Yorgason9Scott C. Steffensen10Kyle B. Bills11Neuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USADepartment of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USANeuroscience Center, Brigham Young University, Provo, UT 84602, USADepartment of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USAPeripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain and projecting to the nucleus accumbens (NAc) of the striatum. We have previously shown that mechanoreceptor activation via whole-body vibration (WBV) ameliorates neuronal and behavioral effects of chronic ethanol exposure. In this study, we employ a similar paradigm to assess the efficacy of WBV as a preventative measure of neuronal and behavioral effects of morphine withdrawal in a Wistar rat model. We demonstrate that concurrent administration of WBV at 80 Hz with morphine over a 5-day period significantly reduced adaptations in VTA GABA neuronal activity and NAc DA release and modulated expression of δ-opioid receptors (DORs) on NAc cholinergic interneurons (CINs) during withdrawal. We also observed a reduction in behavior typically associated with opioid withdrawal. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD) and should be examined translationally in humans.https://www.mdpi.com/1422-0067/24/18/14147opioid abuseaddictionmorphineVTAnucleus accumbensdopamine |
| spellingShingle | Gavin C. Jones Christina A. Small Dallin Z. Otteson Caylor W. Hafen Jacob T. Breinholt Paul D. Flora Matthew D. Burris David W. Sant Tysum R. Ruchti Jordan T. Yorgason Scott C. Steffensen Kyle B. Bills Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model International Journal of Molecular Sciences opioid abuse addiction morphine VTA nucleus accumbens dopamine |
| title | Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model |
| title_full | Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model |
| title_fullStr | Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model |
| title_full_unstemmed | Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model |
| title_short | Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model |
| title_sort | whole body vibration prevents neuronal neurochemical and behavioral effects of morphine withdrawal in a rat model |
| topic | opioid abuse addiction morphine VTA nucleus accumbens dopamine |
| url | https://www.mdpi.com/1422-0067/24/18/14147 |
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