Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies
<i>In vitro</i> and preclinical <i>in vivo</i> research in the last 35 years has clearly highlighted the crucial physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and satellite glial cells/Schwann cells in the central and peripheral nervous...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/7/606 |
| _version_ | 1797212783447638016 |
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| author | Giulia Magni Benedetta Riboldi Stefania Ceruti |
| author_facet | Giulia Magni Benedetta Riboldi Stefania Ceruti |
| author_sort | Giulia Magni |
| collection | DOAJ |
| description | <i>In vitro</i> and preclinical <i>in vivo</i> research in the last 35 years has clearly highlighted the crucial physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and satellite glial cells/Schwann cells in the central and peripheral nervous system, respectively. Several possible pharmacological targets to various neurodegenerative disorders and painful conditions have therefore been successfully identified, including receptors and enzymes, and mediators of neuroinflammation. However, the translation of these promising data to a clinical setting is often hampered by both technical and biological difficulties, making it necessary to perform experiments on human cells and models of the various diseases. In this review we will, therefore, summarize the most relevant data on the contribution of glial cells to human pathologies and on their possible pharmacological modulation based on data obtained in post-mortem tissues and in iPSC-derived human brain cells and organoids. The possibility of an <i>in vivo</i> visualization of glia reaction to neuroinflammation in patients will be also discussed. |
| first_indexed | 2024-04-24T10:47:52Z |
| format | Article |
| id | doaj.art-7c0d8848615249c19b0cc3f6420ce197 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-24T10:47:52Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7c0d8848615249c19b0cc3f6420ce1972024-04-12T13:16:30ZengMDPI AGCells2073-44092024-03-0113760610.3390/cells13070606Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System PathologiesGiulia Magni0Benedetta Riboldi1Stefania Ceruti2Laboratory of Pain Therapy and Neuroimmunology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, ItalyLaboratory of Pain Therapy and Neuroimmunology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, ItalyLaboratory of Pain Therapy and Neuroimmunology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, Italy<i>In vitro</i> and preclinical <i>in vivo</i> research in the last 35 years has clearly highlighted the crucial physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and satellite glial cells/Schwann cells in the central and peripheral nervous system, respectively. Several possible pharmacological targets to various neurodegenerative disorders and painful conditions have therefore been successfully identified, including receptors and enzymes, and mediators of neuroinflammation. However, the translation of these promising data to a clinical setting is often hampered by both technical and biological difficulties, making it necessary to perform experiments on human cells and models of the various diseases. In this review we will, therefore, summarize the most relevant data on the contribution of glial cells to human pathologies and on their possible pharmacological modulation based on data obtained in post-mortem tissues and in iPSC-derived human brain cells and organoids. The possibility of an <i>in vivo</i> visualization of glia reaction to neuroinflammation in patients will be also discussed.https://www.mdpi.com/2073-4409/13/7/606astrocytesmicrogliaiPSCsorganoidsneurodegenerationneuroinflammation |
| spellingShingle | Giulia Magni Benedetta Riboldi Stefania Ceruti Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies Cells astrocytes microglia iPSCs organoids neurodegeneration neuroinflammation |
| title | Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies |
| title_full | Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies |
| title_fullStr | Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies |
| title_full_unstemmed | Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies |
| title_short | Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies |
| title_sort | human glial cells as innovative targets for the therapy of central nervous system pathologies |
| topic | astrocytes microglia iPSCs organoids neurodegeneration neuroinflammation |
| url | https://www.mdpi.com/2073-4409/13/7/606 |
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