Research progress on the role of superoxide dismutase in diabetic retinopathy
Diabetic retinopathy(DR)is the main cause of visual impairment and blindness in working-age people, which is the most common microvascular disease among diabetes complications.Hyperglycemia state can result in the aggravation of oxidative stress, release a large number of reactive oxygen species(ROS...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-05-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2023/5/202305008.pdf |
| _version_ | 1797837848858066944 |
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| author | Qi-Yan Ran Wei Tan |
| author_facet | Qi-Yan Ran Wei Tan |
| author_sort | Qi-Yan Ran |
| collection | DOAJ |
| description | Diabetic retinopathy(DR)is the main cause of visual impairment and blindness in working-age people, which is the most common microvascular disease among diabetes complications.Hyperglycemia state can result in the aggravation of oxidative stress, release a large number of reactive oxygen species(ROS), and cause damage to protein, DNA or RNA in tissues and cells, thus causing cell death. Oxidative stress is considered as one of the important factors for the occurrence and development of DR. Antioxidant defense system is the key component of maintaining redox homeostasis. Superoxide dismutase(SOD)is a major antioxidant enzyme, which maintains the first line of defense in the antioxidant enzyme library. There are three kinds of SOD isozymes in mammals, which mainly protect cells from superoxide damage by accelerating the mutation reaction of SOD. It may delay the occurrence and development of DR by regulating the level of antioxidant enzyme SOD. Currently, the pathogenesis of DR remains unclear. In this paper, the protective effect of antioxidant enzyme SOD on pericytes and ganglion cells in DR was reviewed. |
| first_indexed | 2024-04-09T15:32:21Z |
| format | Article |
| id | doaj.art-7c0de4c3245449cf91e83d51a423dce5 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-09T15:32:21Z |
| publishDate | 2023-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-7c0de4c3245449cf91e83d51a423dce52023-04-28T06:27:01ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-05-0123575976210.3980/j.issn.1672-5123.2023.5.08202305008Research progress on the role of superoxide dismutase in diabetic retinopathyQi-Yan Ran0Wei Tan1Department of Ophthalmology, the Third Affiliated Hospital of Zunyi Medical University;Zunyi City Eye Clinic Medical Center, Zunyi 563000, Guizhou Province, ChinaDepartment of Ophthalmology, the Third Affiliated Hospital of Zunyi Medical University;Zunyi City Eye Clinic Medical Center, Zunyi 563000, Guizhou Province, ChinaDiabetic retinopathy(DR)is the main cause of visual impairment and blindness in working-age people, which is the most common microvascular disease among diabetes complications.Hyperglycemia state can result in the aggravation of oxidative stress, release a large number of reactive oxygen species(ROS), and cause damage to protein, DNA or RNA in tissues and cells, thus causing cell death. Oxidative stress is considered as one of the important factors for the occurrence and development of DR. Antioxidant defense system is the key component of maintaining redox homeostasis. Superoxide dismutase(SOD)is a major antioxidant enzyme, which maintains the first line of defense in the antioxidant enzyme library. There are three kinds of SOD isozymes in mammals, which mainly protect cells from superoxide damage by accelerating the mutation reaction of SOD. It may delay the occurrence and development of DR by regulating the level of antioxidant enzyme SOD. Currently, the pathogenesis of DR remains unclear. In this paper, the protective effect of antioxidant enzyme SOD on pericytes and ganglion cells in DR was reviewed.http://ies.ijo.cn/cn_publish/2023/5/202305008.pdfsuperoxide dismutasediabetic retinopathyoxidative stressreactive oxygen speciesprotective effect |
| spellingShingle | Qi-Yan Ran Wei Tan Research progress on the role of superoxide dismutase in diabetic retinopathy Guoji Yanke Zazhi superoxide dismutase diabetic retinopathy oxidative stress reactive oxygen species protective effect |
| title | Research progress on the role of superoxide dismutase in diabetic retinopathy |
| title_full | Research progress on the role of superoxide dismutase in diabetic retinopathy |
| title_fullStr | Research progress on the role of superoxide dismutase in diabetic retinopathy |
| title_full_unstemmed | Research progress on the role of superoxide dismutase in diabetic retinopathy |
| title_short | Research progress on the role of superoxide dismutase in diabetic retinopathy |
| title_sort | research progress on the role of superoxide dismutase in diabetic retinopathy |
| topic | superoxide dismutase diabetic retinopathy oxidative stress reactive oxygen species protective effect |
| url | http://ies.ijo.cn/cn_publish/2023/5/202305008.pdf |
| work_keys_str_mv | AT qiyanran researchprogressontheroleofsuperoxidedismutaseindiabeticretinopathy AT weitan researchprogressontheroleofsuperoxidedismutaseindiabeticretinopathy |