HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report
Apart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell neuronopathy as well as primary cerebellar atrophy with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-05-01
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| Series: | Case Reports in Neurology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/475544 |
| _version_ | 1818516107146821632 |
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| author | Carolin Hoyer Angelika Alonso Beate Schlotter-Weigel Michael Platten Marc Fatar |
| author_facet | Carolin Hoyer Angelika Alonso Beate Schlotter-Weigel Michael Platten Marc Fatar |
| author_sort | Carolin Hoyer |
| collection | DOAJ |
| description | Apart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell neuronopathy as well as primary cerebellar atrophy without identifiable etiology. We report the case of a patient with progressive cerebellar dysfunction as the primary manifestation of HIV infection. No symptom improvement was seen under combination antiretroviral therapy, which had been established upon diagnosis, but the patient improved rapidly under 4-aminopyridine treatment, which was recommended 1 year later. Our report, adding to the rather small number of reports of HIV-associated cerebellar atrophy and dysfunction as a primary manifestation of HIV infection, draws attention to HIV as a possible differential etiology of a cerebellar syndrome. Further, rapid improvement of symptom severity under 4-aminopyridine treatment warrants further investigation with longer-term follow-up into the effectiveness of this compound in gait disorder associated with HIV infection. |
| first_indexed | 2024-12-11T00:37:43Z |
| format | Article |
| id | doaj.art-7c0fe1b9d5ae4651b126c93322e10605 |
| institution | Directory Open Access Journal |
| issn | 1662-680X |
| language | English |
| last_indexed | 2024-12-11T00:37:43Z |
| publishDate | 2017-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Neurology |
| spelling | doaj.art-7c0fe1b9d5ae4651b126c93322e106052022-12-22T01:27:03ZengKarger PublishersCase Reports in Neurology1662-680X2017-05-019212112610.1159/000475544475544HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case ReportCarolin HoyerAngelika AlonsoBeate Schlotter-WeigelMichael PlattenMarc FatarApart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell neuronopathy as well as primary cerebellar atrophy without identifiable etiology. We report the case of a patient with progressive cerebellar dysfunction as the primary manifestation of HIV infection. No symptom improvement was seen under combination antiretroviral therapy, which had been established upon diagnosis, but the patient improved rapidly under 4-aminopyridine treatment, which was recommended 1 year later. Our report, adding to the rather small number of reports of HIV-associated cerebellar atrophy and dysfunction as a primary manifestation of HIV infection, draws attention to HIV as a possible differential etiology of a cerebellar syndrome. Further, rapid improvement of symptom severity under 4-aminopyridine treatment warrants further investigation with longer-term follow-up into the effectiveness of this compound in gait disorder associated with HIV infection.http://www.karger.com/Article/FullText/475544HIV4-AminopyridineCerebellar syndrome |
| spellingShingle | Carolin Hoyer Angelika Alonso Beate Schlotter-Weigel Michael Platten Marc Fatar HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report Case Reports in Neurology HIV 4-Aminopyridine Cerebellar syndrome |
| title | HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report |
| title_full | HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report |
| title_fullStr | HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report |
| title_full_unstemmed | HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report |
| title_short | HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report |
| title_sort | hiv associated cerebellar dysfunction and improvement with aminopyridine therapy a case report |
| topic | HIV 4-Aminopyridine Cerebellar syndrome |
| url | http://www.karger.com/Article/FullText/475544 |
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