A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH
Aim — The main focus of the project was to identify whether there is any interaction between Ketotifen Fumarate (antihistamine) and domperidone (Antiemetic/dopaminergic antagonist) present or not at simulated gastric and intestinal solutions of different pH. Methods — Using Job’s continuous-variatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Limited liability company «Science and Innovations» (Saratov)
2014-06-01
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| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | http://www.romj.org/node/103 |
| _version_ | 1818737101159530496 |
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| author | Mohammad Aktar Sayeed Fuad Mohammed Farhad Syed Mohammed Tareq Md. Ikram Md. Nurul Islam Saiful Alam Siddique Dipesh Das |
| author_facet | Mohammad Aktar Sayeed Fuad Mohammed Farhad Syed Mohammed Tareq Md. Ikram Md. Nurul Islam Saiful Alam Siddique Dipesh Das |
| author_sort | Mohammad Aktar Sayeed |
| collection | DOAJ |
| description | Aim — The main focus of the project was to identify whether there is any interaction between Ketotifen Fumarate (antihistamine) and domperidone (Antiemetic/dopaminergic antagonist) present or not at simulated gastric and intestinal solutions of different pH. Methods — Using Job’s continuous-variation analysis the possible drug-drug interaction was determined at a fixed temperature (37ºC) at the studied pH. From Job’s continuous-variation analysis the views of drug-drug interaction at different concentration ratio at all pH (0.4, 1.2, 2.0, 2.8, 6.8, and 7.4) except 6.0 were noted. Results — Data obtained from spectroscopic analysis showed decrease in free-drug concentration of both of the drugs analyzed when they were within the same gastric simulated solution. Conclusion — Concurrent administration of Ketotifen Fumarate and domperidone would result in the formation of a stable complex and this is likely to reduce the the rapeutic activities of both drugs. |
| first_indexed | 2024-12-18T00:47:41Z |
| format | Article |
| id | doaj.art-7c103ad0347d4593b3c8f630e5684048 |
| institution | Directory Open Access Journal |
| issn | 2304-3415 |
| language | English |
| last_indexed | 2024-12-18T00:47:41Z |
| publishDate | 2014-06-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj.art-7c103ad0347d4593b3c8f630e56840482022-12-21T21:26:44ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152014-06-0132020410.15275/rusomj.2014.0204A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pHMohammad Aktar SayeedFuad Mohammed FarhadSyed Mohammed TareqMd. IkramMd. Nurul IslamSaiful Alam SiddiqueDipesh DasAim — The main focus of the project was to identify whether there is any interaction between Ketotifen Fumarate (antihistamine) and domperidone (Antiemetic/dopaminergic antagonist) present or not at simulated gastric and intestinal solutions of different pH. Methods — Using Job’s continuous-variation analysis the possible drug-drug interaction was determined at a fixed temperature (37ºC) at the studied pH. From Job’s continuous-variation analysis the views of drug-drug interaction at different concentration ratio at all pH (0.4, 1.2, 2.0, 2.8, 6.8, and 7.4) except 6.0 were noted. Results — Data obtained from spectroscopic analysis showed decrease in free-drug concentration of both of the drugs analyzed when they were within the same gastric simulated solution. Conclusion — Concurrent administration of Ketotifen Fumarate and domperidone would result in the formation of a stable complex and this is likely to reduce the the rapeutic activities of both drugs.http://www.romj.org/node/103drug interactionDomperidonejob’s plotKetotifen fumaratepHspectral pattern |
| spellingShingle | Mohammad Aktar Sayeed Fuad Mohammed Farhad Syed Mohammed Tareq Md. Ikram Md. Nurul Islam Saiful Alam Siddique Dipesh Das A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH Russian Open Medical Journal drug interaction Domperidone job’s plot Ketotifen fumarate pH spectral pattern |
| title | A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH |
| title_full | A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH |
| title_fullStr | A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH |
| title_full_unstemmed | A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH |
| title_short | A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH |
| title_sort | study of in vitro interaction of ketotifen fumarate with domperidone at different gastric and intestinal ph |
| topic | drug interaction Domperidone job’s plot Ketotifen fumarate pH spectral pattern |
| url | http://www.romj.org/node/103 |
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