Pathogenic Variant Profile of Hereditary Cancer Syndromes in a Vietnamese Cohort

Pathogenic Variant Profile of Hereditary Cancer Syndromes in a Vietnamese Cohort

BackgroundHereditary cancer syndromes (HCS) are responsible for 5-10% of cancer cases. Genetic testing to identify pathogenic variants associated with cancer predisposition has not been routinely available in Vietnam. Consequently, the prevalence and genetic landscape of HCS remain unknown.Methods11...

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Main Authors: Van Thuan Tran, Sao Trung Nguyen, Xuan Dung Pham, Thanh Hai Phan, Van Chu Nguyen, Huu Thinh Nguyen, Huu Phuc Nguyen, Phuong Thao Thi Doan, Tuan Anh Le, Bao Toan Nguyen, Thanh Xuan Jasmine, Duy Sinh Nguyen, Hong-Dang Luu Nguyen, Ngoc Mai Nguyen, Duy Xuan Do, Vu Uyen Tran, Hue Hanh Thi Nguyen, Minh Phong Le, Yen Nhi Nguyen, Thanh Thuy Thi Do, Dinh Kiet Truong, Hung Sang Tang, Minh-Duy Phan, Hoai-Nghia Nguyen, Hoa Giang, Lan N. Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
hereditary cancer syndrome
pathogenic variant
genetic carrier screening
carrier frequency
BRCA1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.789659/full

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