D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period.
N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity. Their activation requires the binding of both glutamate and d-serine or glycine as co-agonist. The prevalence of either co-agonist on NMDA-receptor function differs between brain regions and remains undetermined in t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4803205?pdf=render |
| _version_ | 1819056520509259776 |
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| author | Claire N J Meunier Glenn Dallérac Nicolas Le Roux Silvia Sacchi Grégoire Levasseur Muriel Amar Loredano Pollegioni Jean-Pierre Mothet Philippe Fossier |
| author_facet | Claire N J Meunier Glenn Dallérac Nicolas Le Roux Silvia Sacchi Grégoire Levasseur Muriel Amar Loredano Pollegioni Jean-Pierre Mothet Philippe Fossier |
| author_sort | Claire N J Meunier |
| collection | DOAJ |
| description | N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity. Their activation requires the binding of both glutamate and d-serine or glycine as co-agonist. The prevalence of either co-agonist on NMDA-receptor function differs between brain regions and remains undetermined in the visual cortex (VC) at the critical period of postnatal development. Here, we therefore investigated the regulatory role that d-serine and/or glycine may exert on NMDARs function and on synaptic plasticity in the rat VC layer 5 pyramidal neurons of young rats. Using selective enzymatic depletion of d-serine or glycine, we demonstrate that d-serine and not glycine is the endogenous co-agonist of synaptic NMDARs required for the induction and expression of Long Term Potentiation (LTP) at both excitatory and inhibitory synapses. Glycine on the other hand is not involved in synaptic efficacy per se but regulates excitatory and inhibitory neurotransmission by activating strychnine-sensitive glycine receptors, then producing a shunting inhibition that controls neuronal gain and results in a depression of synaptic inputs at the somatic level after dendritic integration. In conclusion, we describe for the first time that in the VC both D-serine and glycine differentially regulate somatic depolarization through the activation of distinct synaptic and extrasynaptic receptors. |
| first_indexed | 2024-12-21T13:24:43Z |
| format | Article |
| id | doaj.art-7c11df82b42642e79060639c47e44527 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T13:24:43Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7c11df82b42642e79060639c47e445272022-12-21T19:02:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015123310.1371/journal.pone.0151233D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period.Claire N J MeunierGlenn DalléracNicolas Le RouxSilvia SacchiGrégoire LevasseurMuriel AmarLoredano PollegioniJean-Pierre MothetPhilippe FossierN-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity. Their activation requires the binding of both glutamate and d-serine or glycine as co-agonist. The prevalence of either co-agonist on NMDA-receptor function differs between brain regions and remains undetermined in the visual cortex (VC) at the critical period of postnatal development. Here, we therefore investigated the regulatory role that d-serine and/or glycine may exert on NMDARs function and on synaptic plasticity in the rat VC layer 5 pyramidal neurons of young rats. Using selective enzymatic depletion of d-serine or glycine, we demonstrate that d-serine and not glycine is the endogenous co-agonist of synaptic NMDARs required for the induction and expression of Long Term Potentiation (LTP) at both excitatory and inhibitory synapses. Glycine on the other hand is not involved in synaptic efficacy per se but regulates excitatory and inhibitory neurotransmission by activating strychnine-sensitive glycine receptors, then producing a shunting inhibition that controls neuronal gain and results in a depression of synaptic inputs at the somatic level after dendritic integration. In conclusion, we describe for the first time that in the VC both D-serine and glycine differentially regulate somatic depolarization through the activation of distinct synaptic and extrasynaptic receptors.http://europepmc.org/articles/PMC4803205?pdf=render |
| spellingShingle | Claire N J Meunier Glenn Dallérac Nicolas Le Roux Silvia Sacchi Grégoire Levasseur Muriel Amar Loredano Pollegioni Jean-Pierre Mothet Philippe Fossier D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period. PLoS ONE |
| title | D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period. |
| title_full | D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period. |
| title_fullStr | D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period. |
| title_full_unstemmed | D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period. |
| title_short | D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period. |
| title_sort | d serine and glycine differentially control neurotransmission during visual cortex critical period |
| url | http://europepmc.org/articles/PMC4803205?pdf=render |
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