The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study
Introduction Multiple studies suggest that cancer leads to activation of clotting and fibrinolysis pathways, elevating the risk of thromboembolic events. Kidney cancer is often complicated by clotting disorders. In this study, we hypothesized that preoperative clotting and fibrinolysis parameters ar...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-04-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/The-influences-of-selected-clotting-and-fibrinolysis-factors-on-survival-of-patients,128845,0,2.html |
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| author | Krzysztof Tupikowski Urszula Jaobsche-Polichn Jadwiga Bittner Kuba Ptaszkowski Agnieszka Halon Romuald Zdrojowy Rajmund Adamiec Izabela Gosk-Bierska |
| author_facet | Krzysztof Tupikowski Urszula Jaobsche-Polichn Jadwiga Bittner Kuba Ptaszkowski Agnieszka Halon Romuald Zdrojowy Rajmund Adamiec Izabela Gosk-Bierska |
| author_sort | Krzysztof Tupikowski |
| collection | DOAJ |
| description | Introduction
Multiple studies suggest that cancer leads to activation of clotting and fibrinolysis pathways, elevating the risk of thromboembolic events. Kidney cancer is often complicated by clotting disorders. In this study, we hypothesized that preoperative clotting and fibrinolysis parameters are altered in healthy volunteers and kidney tumor patients. We also hypothesized that these differences may be associated with survival in patients who have undergone operations due to kidney tumors.
Material and methods
In this study, 96 patients with kidney tumors and 30 healthy volunteers were recruited at a single university center. All patients were assessed for pre-operative serum concentrations of tissue factor (TF), tissue factor pathway inhibitor (TFPI, total TFPI, full-length TFPI, truncated TFPI), plasmin-antiplasmin complex (PAP), thrombin-antithrombin complex (TAT), von Willebrand factor (vWF), clotting factor XIII A1 (FXIIIA1), D-dimers, and fibrinogen. Additionally, standard peripheral blood morphology was evaluated.
Results
Malignant kidney tumors were diagnosed in 85 of 96 tumor patients. In patients with kidney tumors, there were statistically significantly higher concentrations of fibrinogen, D-dimers, TAT, PAF, TF, TFPI, vWF, FXIIIA1, and leukocyte counts compared to the control group. Statistically significant correlations were found between multiple parameters. This points to significant clotting system alterations. Cox stepwise hazard analysis showed that pre-operative fibrinogen and D-Dimer concentrations were significantly associated with survival.
Conclusions
In patients with kidney tumors, multiple clotting and fibrinolysis parameters are significantly altered. Routine pre-operative measures should include determination of fibrinogen and D-dimer concentrations as these markers aid in prediction of survival probability. |
| first_indexed | 2024-03-09T10:47:28Z |
| format | Article |
| id | doaj.art-7c15f454b61a48569bd5f11ee2dee651 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:47:28Z |
| publishDate | 2021-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-7c15f454b61a48569bd5f11ee2dee6512023-12-01T09:50:30ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-04-011941003101010.5114/aoms/128845128845The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective studyKrzysztof Tupikowski0Urszula Jaobsche-Polichn1Jadwiga Bittner2Kuba Ptaszkowski3Agnieszka Halon4Romuald Zdrojowy5Rajmund Adamiec6Izabela Gosk-Bierska7Subdivision of Urology, Wroclaw Comprehensive Cancer Centre, Wroclaw, PolandDepartment of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Wroclaw, PolandDepartment of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Wroclaw, PolandDepartment of Clinical Biomechanics and Physiotherapy in Motor System Disorders, Wroclaw Medical University, Wroclaw, PolandDepartment of Pathomorphology and Oncological Cytology, Wroclaw Medical University, Wroclaw, PolandDepartment of Urology and Oncological Urology, Wroclaw Medical University, Wroclaw, PolandDepartment of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Wroclaw, PolandDepartment of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Wroclaw, PolandIntroduction Multiple studies suggest that cancer leads to activation of clotting and fibrinolysis pathways, elevating the risk of thromboembolic events. Kidney cancer is often complicated by clotting disorders. In this study, we hypothesized that preoperative clotting and fibrinolysis parameters are altered in healthy volunteers and kidney tumor patients. We also hypothesized that these differences may be associated with survival in patients who have undergone operations due to kidney tumors. Material and methods In this study, 96 patients with kidney tumors and 30 healthy volunteers were recruited at a single university center. All patients were assessed for pre-operative serum concentrations of tissue factor (TF), tissue factor pathway inhibitor (TFPI, total TFPI, full-length TFPI, truncated TFPI), plasmin-antiplasmin complex (PAP), thrombin-antithrombin complex (TAT), von Willebrand factor (vWF), clotting factor XIII A1 (FXIIIA1), D-dimers, and fibrinogen. Additionally, standard peripheral blood morphology was evaluated. Results Malignant kidney tumors were diagnosed in 85 of 96 tumor patients. In patients with kidney tumors, there were statistically significantly higher concentrations of fibrinogen, D-dimers, TAT, PAF, TF, TFPI, vWF, FXIIIA1, and leukocyte counts compared to the control group. Statistically significant correlations were found between multiple parameters. This points to significant clotting system alterations. Cox stepwise hazard analysis showed that pre-operative fibrinogen and D-Dimer concentrations were significantly associated with survival. Conclusions In patients with kidney tumors, multiple clotting and fibrinolysis parameters are significantly altered. Routine pre-operative measures should include determination of fibrinogen and D-dimer concentrations as these markers aid in prediction of survival probability.https://www.archivesofmedicalscience.com/The-influences-of-selected-clotting-and-fibrinolysis-factors-on-survival-of-patients,128845,0,2.htmlkidney tumorfibrinogend-dimertissue factorclotting factor xiii |
| spellingShingle | Krzysztof Tupikowski Urszula Jaobsche-Polichn Jadwiga Bittner Kuba Ptaszkowski Agnieszka Halon Romuald Zdrojowy Rajmund Adamiec Izabela Gosk-Bierska The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study Archives of Medical Science kidney tumor fibrinogen d-dimer tissue factor clotting factor xiii |
| title | The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study |
| title_full | The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study |
| title_fullStr | The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study |
| title_full_unstemmed | The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study |
| title_short | The influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors – a prospective study |
| title_sort | influences of selected clotting and fibrinolysis factors on survival of patients with kidney tumors a prospective study |
| topic | kidney tumor fibrinogen d-dimer tissue factor clotting factor xiii |
| url | https://www.archivesofmedicalscience.com/The-influences-of-selected-clotting-and-fibrinolysis-factors-on-survival-of-patients,128845,0,2.html |
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