Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study
Abstract Background Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (TL) and colorectal cancer and its precursors, colorectal polyps, is not...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-05-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4426-2 |
| _version_ | 1818271906773598208 |
|---|---|
| author | Sheetal Hardikar Andrea N. Burnett-Hartman Amanda I. Phipps Melissa P. Upton Lee-Ching Zhu Polly A. Newcomb |
| author_facet | Sheetal Hardikar Andrea N. Burnett-Hartman Amanda I. Phipps Melissa P. Upton Lee-Ching Zhu Polly A. Newcomb |
| author_sort | Sheetal Hardikar |
| collection | DOAJ |
| description | Abstract Background Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (TL) and colorectal cancer and its precursors, colorectal polyps, is not clear. Methods We investigated the relationship between TL and risk of colorectal polyp subtypes in a colonoscopy-based study in western Washington. Participants were 35–79 year-old enrollees at an integrated health care system, who underwent a colonoscopy between 1998 and 2007 (n = 190), completed a self-administered questionnaire, provided blood samples, and were distinguished as having adenomas, serrated polyps, or as polyp-free controls through a standardized pathology review. Telomere length (T) relative to a single copy gene (S) was measured in circulating leukocytes from stored buffy coat samples using quantitative polymerase chain reaction. Multivariable polytomous logistic regression was used to compare case groups with polyp-free controls and other case groups; adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated. Results TL in the shortest tertile (T/S ratio < 0.58) was associated with increased risk of adenomas and serrated polyps [OR (95%CI) were 1.77(0.81–3.88) and 2.98(1.15–7.77), respectively). When evaluated by lesion severity within each pathway, short TL was more strongly associated with advanced adenomas and sessile serrated polyps [OR (95% CI) = 1.90(0.76–4.73) and 3.82(0.86–16.86), respectively], although the associations were not statistically significant. Conclusions Our results suggest that short TL may be associated with an increased risk of colorectal polyps in both the adenoma-carcinoma and serrated pathways. The risk was particularly notable for sessile serrated polyps, although the association was not statistically significant and sample size was limited. |
| first_indexed | 2024-12-12T21:33:37Z |
| format | Article |
| id | doaj.art-7c160c5d7b534d909fa56f2adda75a67 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-12T21:33:37Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7c160c5d7b534d909fa56f2adda75a672022-12-22T00:11:14ZengBMCBMC Cancer1471-24072018-05-011811510.1186/s12885-018-4426-2Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control studySheetal Hardikar0Andrea N. Burnett-Hartman1Amanda I. Phipps2Melissa P. Upton3Lee-Ching Zhu4Polly A. Newcomb5Huntsman Cancer Institute, University of UtahPublic Health Sciences Division, Fred Hutchinson Cancer Research CenterPublic Health Sciences Division, Fred Hutchinson Cancer Research CenterDepartment of Pathology, School of Medicine, University of WashingtonKaiser Permanente Washington Health Research InstitutePublic Health Sciences Division, Fred Hutchinson Cancer Research CenterAbstract Background Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (TL) and colorectal cancer and its precursors, colorectal polyps, is not clear. Methods We investigated the relationship between TL and risk of colorectal polyp subtypes in a colonoscopy-based study in western Washington. Participants were 35–79 year-old enrollees at an integrated health care system, who underwent a colonoscopy between 1998 and 2007 (n = 190), completed a self-administered questionnaire, provided blood samples, and were distinguished as having adenomas, serrated polyps, or as polyp-free controls through a standardized pathology review. Telomere length (T) relative to a single copy gene (S) was measured in circulating leukocytes from stored buffy coat samples using quantitative polymerase chain reaction. Multivariable polytomous logistic regression was used to compare case groups with polyp-free controls and other case groups; adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated. Results TL in the shortest tertile (T/S ratio < 0.58) was associated with increased risk of adenomas and serrated polyps [OR (95%CI) were 1.77(0.81–3.88) and 2.98(1.15–7.77), respectively). When evaluated by lesion severity within each pathway, short TL was more strongly associated with advanced adenomas and sessile serrated polyps [OR (95% CI) = 1.90(0.76–4.73) and 3.82(0.86–16.86), respectively], although the associations were not statistically significant. Conclusions Our results suggest that short TL may be associated with an increased risk of colorectal polyps in both the adenoma-carcinoma and serrated pathways. The risk was particularly notable for sessile serrated polyps, although the association was not statistically significant and sample size was limited.http://link.springer.com/article/10.1186/s12885-018-4426-2AdenomasSerrated polypsSessile serrated polypsAdvanced adenomasTelomere length |
| spellingShingle | Sheetal Hardikar Andrea N. Burnett-Hartman Amanda I. Phipps Melissa P. Upton Lee-Ching Zhu Polly A. Newcomb Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study BMC Cancer Adenomas Serrated polyps Sessile serrated polyps Advanced adenomas Telomere length |
| title | Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study |
| title_full | Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study |
| title_fullStr | Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study |
| title_full_unstemmed | Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study |
| title_short | Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study |
| title_sort | telomere length differences between colorectal polyp subtypes a colonoscopy based case control study |
| topic | Adenomas Serrated polyps Sessile serrated polyps Advanced adenomas Telomere length |
| url | http://link.springer.com/article/10.1186/s12885-018-4426-2 |
| work_keys_str_mv | AT sheetalhardikar telomerelengthdifferencesbetweencolorectalpolypsubtypesacolonoscopybasedcasecontrolstudy AT andreanburnetthartman telomerelengthdifferencesbetweencolorectalpolypsubtypesacolonoscopybasedcasecontrolstudy AT amandaiphipps telomerelengthdifferencesbetweencolorectalpolypsubtypesacolonoscopybasedcasecontrolstudy AT melissapupton telomerelengthdifferencesbetweencolorectalpolypsubtypesacolonoscopybasedcasecontrolstudy AT leechingzhu telomerelengthdifferencesbetweencolorectalpolypsubtypesacolonoscopybasedcasecontrolstudy AT pollyanewcomb telomerelengthdifferencesbetweencolorectalpolypsubtypesacolonoscopybasedcasecontrolstudy |