Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?

Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?

Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether genetic predisposition to tobacco smoking, alcohol consumption, and higher body mass index (BMI) moderates the effect of these phenotypes on blood DNA methylation. We cal...

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Bibliographic Details
Main Authors:	Chenglong Yu, Allison M Hodge, Ee Ming Wong, Jihoon E Joo, Enes Makalic, Daniel F Schmidt, Daniel D Buchanan, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugué
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Series:	Epigenetics
Subjects:	dna methylation gene–environment interaction lifestyle polygenic score cpg site epigenetic ageing
Online Access:	http://dx.doi.org/10.1080/15592294.2022.2088038

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