Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal
Background. Meal ingestion induces a postprandial experience that involves homeostatic and hedonic sensations. Our aim was to determine the effect of aversive conditioning on the postprandial reward of a comfort meal. Methods: A sham-controlled, randomised, parallel, single-blind study was performed...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/10/2247 |
| _version_ | 1797598847252299776 |
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| author | Adoracion Nieto Dan M. Livovsky Fernando Azpiroz |
| author_facet | Adoracion Nieto Dan M. Livovsky Fernando Azpiroz |
| author_sort | Adoracion Nieto |
| collection | DOAJ |
| description | Background. Meal ingestion induces a postprandial experience that involves homeostatic and hedonic sensations. Our aim was to determine the effect of aversive conditioning on the postprandial reward of a comfort meal. Methods: A sham-controlled, randomised, parallel, single-blind study was performed on 12 healthy women (6 per group). A comfort meal was tested before and after coupling the meal with an aversive sensation (conditioning intervention), induced by infusion of lipids via a thin naso-duodenal catheter; in the pre- and post-conditioning tests and in the control group, a sham infusion was performed. Participants were instructed that two recipes of a tasty humus would be tested; however, the same meal was administered with a colour additive in the conditioning and post-conditioning tests. Digestive well-being (primary outcome) was measured every 10 min before and 60 min after ingestion using graded scales. Results: In the aversive conditioning group, the comfort meal in the pre-conditioning test induced a pleasant postprandial experience, which was significantly lower in the post-conditioning test; the effect of aversive conditioning (change from pre- to post-conditioning) was significant as compared to sham conditioning in the control group, which showed no differences between study days. Conclusion: The hedonic postprandial response to a comfort meal in healthy women is impaired by aversive conditioning. ClinicalTrials.gov ID: NCT04938934. |
| first_indexed | 2024-03-11T03:26:30Z |
| format | Article |
| id | doaj.art-7c18790cebc04d8090f697069f34bc17 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T03:26:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7c18790cebc04d8090f697069f34bc172023-11-18T02:43:41ZengMDPI AGNutrients2072-66432023-05-011510224710.3390/nu15102247Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort MealAdoracion Nieto0Dan M. Livovsky1Fernando Azpiroz2Digestive System Research Unit, University Hospital Vall d’Hebron, 08035 Barcelona, SpainDigestive System Research Unit, University Hospital Vall d’Hebron, 08035 Barcelona, SpainDigestive System Research Unit, University Hospital Vall d’Hebron, 08035 Barcelona, SpainBackground. Meal ingestion induces a postprandial experience that involves homeostatic and hedonic sensations. Our aim was to determine the effect of aversive conditioning on the postprandial reward of a comfort meal. Methods: A sham-controlled, randomised, parallel, single-blind study was performed on 12 healthy women (6 per group). A comfort meal was tested before and after coupling the meal with an aversive sensation (conditioning intervention), induced by infusion of lipids via a thin naso-duodenal catheter; in the pre- and post-conditioning tests and in the control group, a sham infusion was performed. Participants were instructed that two recipes of a tasty humus would be tested; however, the same meal was administered with a colour additive in the conditioning and post-conditioning tests. Digestive well-being (primary outcome) was measured every 10 min before and 60 min after ingestion using graded scales. Results: In the aversive conditioning group, the comfort meal in the pre-conditioning test induced a pleasant postprandial experience, which was significantly lower in the post-conditioning test; the effect of aversive conditioning (change from pre- to post-conditioning) was significant as compared to sham conditioning in the control group, which showed no differences between study days. Conclusion: The hedonic postprandial response to a comfort meal in healthy women is impaired by aversive conditioning. ClinicalTrials.gov ID: NCT04938934.https://www.mdpi.com/2072-6643/15/10/2247Pavlovian conditioningaversive conditioningeating behaviourdigestive sensationspostprandial symptomsdigestive well-being |
| spellingShingle | Adoracion Nieto Dan M. Livovsky Fernando Azpiroz Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal Nutrients Pavlovian conditioning aversive conditioning eating behaviour digestive sensations postprandial symptoms digestive well-being |
| title | Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal |
| title_full | Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal |
| title_fullStr | Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal |
| title_full_unstemmed | Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal |
| title_short | Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal |
| title_sort | conditioning by a previous experience impairs the rewarding value of a comfort meal |
| topic | Pavlovian conditioning aversive conditioning eating behaviour digestive sensations postprandial symptoms digestive well-being |
| url | https://www.mdpi.com/2072-6643/15/10/2247 |
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