Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling

Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling

Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events such as epithelial damage and concomitant influx of m...

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Bibliographic Details
Main Authors: Martje N. Erkelens, Gera Goverse, Tanja Konijn, Rosalie Molenaar, Marieke R. Beijer, Jan Van den Bossche, Kyra E. de Goede, Sanne G. S. Verberk, Wouter J. de Jonge, Joke M. M. den Haan, Reina E. Mebius
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
macrophage
retinoic acid
Dectin-1
pro-inflammatory
anti-inflammatory
vitamin A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00551/full

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