Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis
According to the recent findings, autophagy modulation is being a potential therapeutic target in the management of ischemic stroke in a pre-clinical setting. However, the pros and cons of autophagic response strongly depend on the activation time of autophagy after injury. In this systematic rev...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-01-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://article.imrpress.com/journal/JIN/21/1/10.31083/j.jin2101011/1757-448X-21-1-011.pdf |
| _version_ | 1818038481125900288 |
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| author | Aysa Rezabakhsh Nafiseh Vahed Hossein Hosseinifard Reza Rahbarghazi Fatemeh Salehnia Yalda Sadeghpour Sarvin Sanaie |
| author_facet | Aysa Rezabakhsh Nafiseh Vahed Hossein Hosseinifard Reza Rahbarghazi Fatemeh Salehnia Yalda Sadeghpour Sarvin Sanaie |
| author_sort | Aysa Rezabakhsh |
| collection | DOAJ |
| description | According to the recent findings, autophagy modulation is being a potential
therapeutic target in the management of ischemic stroke in a pre-clinical
setting. However, the pros and cons of autophagic response strongly depend on the
activation time of autophagy after injury. In this systematic review, we aimed to
explore the impacts of pharmacological modulation of autophagy on infarct size in
experimental ischemic stroke models. Based on our preliminary search, 3551
publications were identified. Of twenty-nine publications that met the inclusion
criteria, twenty studies reported infarct volume reduction by percentage (%)
with no evidence of any publication bias while nine studies reported by mm3,
which had publication bias (39.25 units, standardized mean differences (SMD) =
41.92, 95% confidence interval (CI): 30.33 to 53.51). Based on a meta-analysis,
the point estimate (pooled mean difference) for improvement of infarct volume
during autophagy modulation according to the mm3 and percentage were 35.64
(mean differences (MD) = 35.64, 95% CI: 26.43 to 44.85, z-value = 7.58,
p-value < 0.001) and 14.38 (MD = 14.38, 95% CI = 10.50 to 18.26,
z-value = 7.26, p < 0.001) units, respectively. Despite the undeniable
role of autophagy in ischemic stroke, the dichotomous effects of autophagy
regarding infarct volume reduction should be taken into account. Based on our
findings, the studies included in this meta-analysis mostly reported a negative
relation between autophagy induction and stroke volume development due to
over-activity of autophagy upon the severe ischemic stroke; therefore, further
pre-clinical studies are also recommended to establish adjusted autophagy with
considering a time-dependent effect as a promising therapeutic target. |
| first_indexed | 2024-12-10T07:43:25Z |
| format | Article |
| id | doaj.art-7c1b98dac55543c786a8ad3b7fadab49 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-12-10T07:43:25Z |
| publishDate | 2022-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-7c1b98dac55543c786a8ad3b7fadab492022-12-22T01:57:14ZengIMR PressJournal of Integrative Neuroscience0219-63522022-01-0121101110.31083/j.jin2101011S0219-6352(22)00271-6Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysisAysa Rezabakhsh0Nafiseh Vahed1Hossein Hosseinifard2Reza Rahbarghazi3Fatemeh Salehnia4Yalda Sadeghpour5Sarvin Sanaie6Cardiovascular Research Center, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranResearch Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranResearch Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranStem Cell Research Center, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranResearch Development & Coordination Center, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranNeurosciences Research Center, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranNeurosciences Research Center, Tabriz University of Medical Sciences, 5166614766 Tabriz, IranAccording to the recent findings, autophagy modulation is being a potential therapeutic target in the management of ischemic stroke in a pre-clinical setting. However, the pros and cons of autophagic response strongly depend on the activation time of autophagy after injury. In this systematic review, we aimed to explore the impacts of pharmacological modulation of autophagy on infarct size in experimental ischemic stroke models. Based on our preliminary search, 3551 publications were identified. Of twenty-nine publications that met the inclusion criteria, twenty studies reported infarct volume reduction by percentage (%) with no evidence of any publication bias while nine studies reported by mm3, which had publication bias (39.25 units, standardized mean differences (SMD) = 41.92, 95% confidence interval (CI): 30.33 to 53.51). Based on a meta-analysis, the point estimate (pooled mean difference) for improvement of infarct volume during autophagy modulation according to the mm3 and percentage were 35.64 (mean differences (MD) = 35.64, 95% CI: 26.43 to 44.85, z-value = 7.58, p-value < 0.001) and 14.38 (MD = 14.38, 95% CI = 10.50 to 18.26, z-value = 7.26, p < 0.001) units, respectively. Despite the undeniable role of autophagy in ischemic stroke, the dichotomous effects of autophagy regarding infarct volume reduction should be taken into account. Based on our findings, the studies included in this meta-analysis mostly reported a negative relation between autophagy induction and stroke volume development due to over-activity of autophagy upon the severe ischemic stroke; therefore, further pre-clinical studies are also recommended to establish adjusted autophagy with considering a time-dependent effect as a promising therapeutic target.https://article.imrpress.com/journal/JIN/21/1/10.31083/j.jin2101011/1757-448X-21-1-011.pdfautophagydual effectsischemic strokepre-clinical setting |
| spellingShingle | Aysa Rezabakhsh Nafiseh Vahed Hossein Hosseinifard Reza Rahbarghazi Fatemeh Salehnia Yalda Sadeghpour Sarvin Sanaie Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis Journal of Integrative Neuroscience autophagy dual effects ischemic stroke pre-clinical setting |
| title | Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis |
| title_full | Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis |
| title_fullStr | Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis |
| title_full_unstemmed | Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis |
| title_short | Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis |
| title_sort | dichotomous effects of autophagy on infarct volume in experimental permanent transient ischemic stroke model a systematic review and meta analysis |
| topic | autophagy dual effects ischemic stroke pre-clinical setting |
| url | https://article.imrpress.com/journal/JIN/21/1/10.31083/j.jin2101011/1757-448X-21-1-011.pdf |
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