The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study
Background: The frequency of clinicoepidemiological variants of Kaposi's sarcoma (KS) differs markedly throughout the world. The iatrogenic variant is mainly associated with the use of immunosuppressive therapy. Aims: We aimed to investigate the distribution of KS variants in our practice and e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2019;volume=64;issue=5;spage=392;epage=399;aulast=Baykal |
| _version_ | 1817976981615017984 |
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| author | Can Baykal Tugba Atci Nesimi Buyukbabani Armagan Kutlay |
| author_facet | Can Baykal Tugba Atci Nesimi Buyukbabani Armagan Kutlay |
| author_sort | Can Baykal |
| collection | DOAJ |
| description | Background: The frequency of clinicoepidemiological variants of Kaposi's sarcoma (KS) differs markedly throughout the world. The iatrogenic variant is mainly associated with the use of immunosuppressive therapy. Aims: We aimed to investigate the distribution of KS variants in our practice and elucidate the underlying causes of iatrogenic KS. Methods: Consecutive KS patients seen in a single tertiary center were grouped according to the tumor variants and iatrogenic KS patients were evaluated about associated conditions. Results: Among 137 patients, classic variant was the most frequent presentation (n = 88), followed by iatrogenic (n = 37) variant. Among the iatrogenic group, ten were transplant recipients. In 16 iatrogenic KS patients, systemic corticosteroid was used, in four for myasthenia gravis (MG) and in three for rheumatoid arthritis. In three patients, KS developed under topical corticosteroid (TC) treatment. Among iatrogenic KS patients, ten of them had a second primary neoplasm and one had congenital immunodeficiency syndrome. Conclusions: Our study revealed one of the highest rates for iatrogenic KS (27%) reported in the literature. Besides well-known causes, relatively frequent association with MG was remarkable. Usage of different forms of TCs was the cause of KS in a few cases. |
| first_indexed | 2024-04-13T22:10:08Z |
| format | Article |
| id | doaj.art-7c1c7580b6a146909c297562f5f156d3 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-04-13T22:10:08Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-7c1c7580b6a146909c297562f5f156d32022-12-22T02:27:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112019-01-0164539239910.4103/ijd.IJD_217_18The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective studyCan BaykalTugba AtciNesimi BuyukbabaniArmagan KutlayBackground: The frequency of clinicoepidemiological variants of Kaposi's sarcoma (KS) differs markedly throughout the world. The iatrogenic variant is mainly associated with the use of immunosuppressive therapy. Aims: We aimed to investigate the distribution of KS variants in our practice and elucidate the underlying causes of iatrogenic KS. Methods: Consecutive KS patients seen in a single tertiary center were grouped according to the tumor variants and iatrogenic KS patients were evaluated about associated conditions. Results: Among 137 patients, classic variant was the most frequent presentation (n = 88), followed by iatrogenic (n = 37) variant. Among the iatrogenic group, ten were transplant recipients. In 16 iatrogenic KS patients, systemic corticosteroid was used, in four for myasthenia gravis (MG) and in three for rheumatoid arthritis. In three patients, KS developed under topical corticosteroid (TC) treatment. Among iatrogenic KS patients, ten of them had a second primary neoplasm and one had congenital immunodeficiency syndrome. Conclusions: Our study revealed one of the highest rates for iatrogenic KS (27%) reported in the literature. Besides well-known causes, relatively frequent association with MG was remarkable. Usage of different forms of TCs was the cause of KS in a few cases.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2019;volume=64;issue=5;spage=392;epage=399;aulast=BaykalCorticosteroidiatrogenicKaposi's sarcomamyasthenia gravismycosis fungoides |
| spellingShingle | Can Baykal Tugba Atci Nesimi Buyukbabani Armagan Kutlay The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study Indian Journal of Dermatology Corticosteroid iatrogenic Kaposi's sarcoma myasthenia gravis mycosis fungoides |
| title | The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study |
| title_full | The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study |
| title_fullStr | The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study |
| title_full_unstemmed | The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study |
| title_short | The spectrum of underlying causes of iatrogenic Kaposi's sarcoma in a large series: A retrospective study |
| title_sort | spectrum of underlying causes of iatrogenic kaposi s sarcoma in a large series a retrospective study |
| topic | Corticosteroid iatrogenic Kaposi's sarcoma myasthenia gravis mycosis fungoides |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2019;volume=64;issue=5;spage=392;epage=399;aulast=Baykal |
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