Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes

Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes

Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR) to levodopa, levodopa-induced postsynap...

Full description

Bibliographic Details
Main Authors: C. Marin, E. Aguilar, G. Mengod, R. Cortés, M.C. Rodríguez-Oroz, J.A. Obeso
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Levodopa
Entacapone
6-Hydroxydopamine
Preproenkephalin
Preprodynorphin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001721

Similar Items

Similar Items