Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma
Objectives: Endometrial carcinoma (EC) is a common gynecologic malignancy in the female genital tract, especially in postmenopausal women. The current study aimed to analyze Papanicolaou (Pap) smear in patients with EC to assess the relationship between EC and abnormal cells in Pap smear, ABO blood...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
| Series: | Gynecology and Minimally Invasive Therapy |
| Subjects: | |
| Online Access: | http://www.e-gmit.com/article.asp?issn=2213-3070;year=2020;volume=9;issue=3;spage=131;epage=138;aulast=Hosseini |
| _version_ | 1828464854036381696 |
|---|---|
| author | Maryam Sadat Hosseini Shima Mohammadian Farah Farzaneh Maliheh Arab Tahereh Ashrafganjoei |
| author_facet | Maryam Sadat Hosseini Shima Mohammadian Farah Farzaneh Maliheh Arab Tahereh Ashrafganjoei |
| author_sort | Maryam Sadat Hosseini |
| collection | DOAJ |
| description | Objectives: Endometrial carcinoma (EC) is a common gynecologic malignancy in the female genital tract, especially in postmenopausal women. The current study aimed to analyze Papanicolaou (Pap) smear in patients with EC to assess the relationship between EC and abnormal cells in Pap smear, ABO blood group, and hemoglobin anemia.Materials and Methods: A retrospective study was conducted on 175 patients with EC in Imam Hossein Hospital, Tehran, Iran, during the period from 2013 to 2019. The histology information of cases was extracted from the hospital database, and Pap smear slides were taken from pathological archives. The acquired information and slides were then reviewed by an expert pathologist in the hospital. The data were analyzed in SPSS (version 18) by the Chi-square test, Fisher's exact test, and independent-samples t-test. P < 0.05 was assigned as significant.Results: The mean age of patients was 54.47 ± 11.34, ranging from 32 to 85 years, and 31.4% of the patients were premenopausal women. Grade III, invasion ≥ 50% of myometrial, and advanced stage (III and IV) were diagnosed in 30%, 7.4%, and 22.86% of the patients, respectively. The most common histological types of EC were endometrioid (66.9%), papillary (10.3%), and malignant mixed Mullerian tumor (5.7%). The abnormal Pap smear was achieved only in 37 EC patients (21.1%). Endometrial cells, atypical squamous cells of undetermined significance, and atypical glandular cells were observed in 56.8%, 29.7%, and 13.5% of the patients > 40 years of age with abnormal Pap smears, respectively. In patients with normal Pap smears, the most common results were inflammation in 75.1% and atrophy in 14.6% of the patients. Abnormal uterine bleeding was the most important problem observed in patients with EC.Conclusion: The efficacy of Pap smear in detecting EC is limited. Therefore, women with EC, >40 years of age, with heavy bleeding, anemia, O blood group, inflammation, and atrophy in Pap smear in the past 3 years need to be precisely checked up for EC. These items can be added as new criteria for EC screening procedures. |
| first_indexed | 2024-12-11T03:21:45Z |
| format | Article |
| id | doaj.art-7c1cd5f974f748f2a553a127f4295107 |
| institution | Directory Open Access Journal |
| issn | 2213-3070 |
| language | English |
| last_indexed | 2024-12-11T03:21:45Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Gynecology and Minimally Invasive Therapy |
| spelling | doaj.art-7c1cd5f974f748f2a553a127f42951072022-12-22T01:22:37ZengWolters Kluwer Medknow PublicationsGynecology and Minimally Invasive Therapy2213-30702020-01-019313113810.4103/GMIT.GMIT_93_19Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinomaMaryam Sadat HosseiniShima MohammadianFarah FarzanehMaliheh ArabTahereh AshrafganjoeiObjectives: Endometrial carcinoma (EC) is a common gynecologic malignancy in the female genital tract, especially in postmenopausal women. The current study aimed to analyze Papanicolaou (Pap) smear in patients with EC to assess the relationship between EC and abnormal cells in Pap smear, ABO blood group, and hemoglobin anemia.Materials and Methods: A retrospective study was conducted on 175 patients with EC in Imam Hossein Hospital, Tehran, Iran, during the period from 2013 to 2019. The histology information of cases was extracted from the hospital database, and Pap smear slides were taken from pathological archives. The acquired information and slides were then reviewed by an expert pathologist in the hospital. The data were analyzed in SPSS (version 18) by the Chi-square test, Fisher's exact test, and independent-samples t-test. P < 0.05 was assigned as significant.Results: The mean age of patients was 54.47 ± 11.34, ranging from 32 to 85 years, and 31.4% of the patients were premenopausal women. Grade III, invasion ≥ 50% of myometrial, and advanced stage (III and IV) were diagnosed in 30%, 7.4%, and 22.86% of the patients, respectively. The most common histological types of EC were endometrioid (66.9%), papillary (10.3%), and malignant mixed Mullerian tumor (5.7%). The abnormal Pap smear was achieved only in 37 EC patients (21.1%). Endometrial cells, atypical squamous cells of undetermined significance, and atypical glandular cells were observed in 56.8%, 29.7%, and 13.5% of the patients > 40 years of age with abnormal Pap smears, respectively. In patients with normal Pap smears, the most common results were inflammation in 75.1% and atrophy in 14.6% of the patients. Abnormal uterine bleeding was the most important problem observed in patients with EC.Conclusion: The efficacy of Pap smear in detecting EC is limited. Therefore, women with EC, >40 years of age, with heavy bleeding, anemia, O blood group, inflammation, and atrophy in Pap smear in the past 3 years need to be precisely checked up for EC. These items can be added as new criteria for EC screening procedures.http://www.e-gmit.com/article.asp?issn=2213-3070;year=2020;volume=9;issue=3;spage=131;epage=138;aulast=Hosseiniendometrial cancermyometrial invasionpapanicolaou smearpostmenopausal women |
| spellingShingle | Maryam Sadat Hosseini Shima Mohammadian Farah Farzaneh Maliheh Arab Tahereh Ashrafganjoei Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma Gynecology and Minimally Invasive Therapy endometrial cancer myometrial invasion papanicolaou smear postmenopausal women |
| title | Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma |
| title_full | Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma |
| title_fullStr | Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma |
| title_full_unstemmed | Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma |
| title_short | Diagnostic role of papanicolaou smear, hemoglobin, blood group, and other clinical symptoms in detecting endometrial carcinoma: A clinicopathological study of 175 Iranian women with endometrial carcinoma |
| title_sort | diagnostic role of papanicolaou smear hemoglobin blood group and other clinical symptoms in detecting endometrial carcinoma a clinicopathological study of 175 iranian women with endometrial carcinoma |
| topic | endometrial cancer myometrial invasion papanicolaou smear postmenopausal women |
| url | http://www.e-gmit.com/article.asp?issn=2213-3070;year=2020;volume=9;issue=3;spage=131;epage=138;aulast=Hosseini |
| work_keys_str_mv | AT maryamsadathosseini diagnosticroleofpapanicolaousmearhemoglobinbloodgroupandotherclinicalsymptomsindetectingendometrialcarcinomaaclinicopathologicalstudyof175iranianwomenwithendometrialcarcinoma AT shimamohammadian diagnosticroleofpapanicolaousmearhemoglobinbloodgroupandotherclinicalsymptomsindetectingendometrialcarcinomaaclinicopathologicalstudyof175iranianwomenwithendometrialcarcinoma AT farahfarzaneh diagnosticroleofpapanicolaousmearhemoglobinbloodgroupandotherclinicalsymptomsindetectingendometrialcarcinomaaclinicopathologicalstudyof175iranianwomenwithendometrialcarcinoma AT maliheharab diagnosticroleofpapanicolaousmearhemoglobinbloodgroupandotherclinicalsymptomsindetectingendometrialcarcinomaaclinicopathologicalstudyof175iranianwomenwithendometrialcarcinoma AT taherehashrafganjoei diagnosticroleofpapanicolaousmearhemoglobinbloodgroupandotherclinicalsymptomsindetectingendometrialcarcinomaaclinicopathologicalstudyof175iranianwomenwithendometrialcarcinoma |