Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients
BackgroundThe coronavirus disease (COVID-19) pandemic, which has been ongoing for more than 2 years, has become one of the largest public health issues. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the most important interventions to mitigate t...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.974848/full |
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| author | Wen Zhang Wen Zhang Wen Zhang Qian Chen Qian Chen Qian Chen Jinghong Dai Jiaming Lu Jiaming Lu Jiaming Lu Jie Li Yongxiang Yi Linqing Fu Xin Li Jiani Liu Jinlong Liufu Cong Long Bing Zhang Bing Zhang Bing Zhang Bing Zhang |
| author_facet | Wen Zhang Wen Zhang Wen Zhang Qian Chen Qian Chen Qian Chen Jinghong Dai Jiaming Lu Jiaming Lu Jiaming Lu Jie Li Yongxiang Yi Linqing Fu Xin Li Jiani Liu Jinlong Liufu Cong Long Bing Zhang Bing Zhang Bing Zhang Bing Zhang |
| author_sort | Wen Zhang |
| collection | DOAJ |
| description | BackgroundThe coronavirus disease (COVID-19) pandemic, which has been ongoing for more than 2 years, has become one of the largest public health issues. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the most important interventions to mitigate the COVID-19 pandemic. Our objective is to investigate the relationship between vaccination status and time to seroconversion.MethodsWe conducted a cross-sectional observational study during the SARS-CoV-2 B.1.617.2 outbreak in Jiangsu, China. Participants who infected with the B.1.617.2 variant were enrolled. Cognitive performance, quality of life, emotional state, chest computed tomography (CT) score and seroconversion time were evaluated for each participant. Statistical analyses were performed using one-way ANOVA, univariate and multivariate regression analyses, Pearson correlation, and mediation analysis.ResultsA total of 91 patients were included in the analysis, of whom 37.3, 25.3, and 37.3% were unvaccinated, partially vaccinated, and fully vaccinated, respectively. Quality of life was impaired in 30.7% of patients, especially for mental component summary (MCS) score. Vaccination status, subjective cognitive decline, and depression were risk factors for quality-of-life impairment. The chest CT score mediated the relationship of vaccination status with the MCS score, and the MCS score mediated the relationship of the chest CT score with time to seroconversion.ConclusionFull immunization course with an inactivated vaccine effectively lowered the chest CT score and improved quality of life in hospitalized patients. Vaccination status could influence time to seroconversion by affecting CT score and MCS score indirectly. Our study emphasizes the importance of continuous efforts in encouraging a full vaccination course. |
| first_indexed | 2024-04-11T07:33:07Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T07:33:07Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-7c1dd60b40d8400797a3c134bcc746aa2022-12-22T04:36:49ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.974848974848Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patientsWen Zhang0Wen Zhang1Wen Zhang2Qian Chen3Qian Chen4Qian Chen5Jinghong Dai6Jiaming Lu7Jiaming Lu8Jiaming Lu9Jie Li10Yongxiang Yi11Linqing Fu12Xin Li13Jiani Liu14Jinlong Liufu15Cong Long16Bing Zhang17Bing Zhang18Bing Zhang19Bing Zhang20Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaMedical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaMedical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, ChinaDepartment of Pulmonary and Critical Care Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaMedical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, ChinaDepartment of Infectious Disease, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Infectious Diseases, The Second Hospital of Nanjing, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaMedical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, ChinaInstitute of Brain Science, Nanjing University, Nanjing, ChinaBackgroundThe coronavirus disease (COVID-19) pandemic, which has been ongoing for more than 2 years, has become one of the largest public health issues. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the most important interventions to mitigate the COVID-19 pandemic. Our objective is to investigate the relationship between vaccination status and time to seroconversion.MethodsWe conducted a cross-sectional observational study during the SARS-CoV-2 B.1.617.2 outbreak in Jiangsu, China. Participants who infected with the B.1.617.2 variant were enrolled. Cognitive performance, quality of life, emotional state, chest computed tomography (CT) score and seroconversion time were evaluated for each participant. Statistical analyses were performed using one-way ANOVA, univariate and multivariate regression analyses, Pearson correlation, and mediation analysis.ResultsA total of 91 patients were included in the analysis, of whom 37.3, 25.3, and 37.3% were unvaccinated, partially vaccinated, and fully vaccinated, respectively. Quality of life was impaired in 30.7% of patients, especially for mental component summary (MCS) score. Vaccination status, subjective cognitive decline, and depression were risk factors for quality-of-life impairment. The chest CT score mediated the relationship of vaccination status with the MCS score, and the MCS score mediated the relationship of the chest CT score with time to seroconversion.ConclusionFull immunization course with an inactivated vaccine effectively lowered the chest CT score and improved quality of life in hospitalized patients. Vaccination status could influence time to seroconversion by affecting CT score and MCS score indirectly. Our study emphasizes the importance of continuous efforts in encouraging a full vaccination course.https://www.frontiersin.org/articles/10.3389/fpubh.2022.974848/fullCOVID-19SARS-CoV-2B.1.617.2 Delta variantvaccinationmental healthseroconversion time |
| spellingShingle | Wen Zhang Wen Zhang Wen Zhang Qian Chen Qian Chen Qian Chen Jinghong Dai Jiaming Lu Jiaming Lu Jiaming Lu Jie Li Yongxiang Yi Linqing Fu Xin Li Jiani Liu Jinlong Liufu Cong Long Bing Zhang Bing Zhang Bing Zhang Bing Zhang Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients Frontiers in Public Health COVID-19 SARS-CoV-2 B.1.617.2 Delta variant vaccination mental health seroconversion time |
| title | Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients |
| title_full | Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients |
| title_fullStr | Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients |
| title_full_unstemmed | Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients |
| title_short | Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patients |
| title_sort | mental health and chest ct scores mediate the relationship between covid 19 vaccination status and seroconversion time a cross sectional observational study in b 1 617 2 delta infection patients |
| topic | COVID-19 SARS-CoV-2 B.1.617.2 Delta variant vaccination mental health seroconversion time |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.974848/full |
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