Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves
The quantized vibration of chemical bonds provides a way of detecting specific molecules in a complex tissue environment. Unlike pure optical methods, for which imaging depth is limited to a few hundred micrometers by significant optical scattering, photoacoustic detection of vibrational absorption...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-03-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597916300027 |
| _version_ | 1819086310727483392 |
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| author | Jie Hui Rui Li Evan H. Phillips Craig J. Goergen Michael Sturek Ji-Xin Cheng |
| author_facet | Jie Hui Rui Li Evan H. Phillips Craig J. Goergen Michael Sturek Ji-Xin Cheng |
| author_sort | Jie Hui |
| collection | DOAJ |
| description | The quantized vibration of chemical bonds provides a way of detecting specific molecules in a complex tissue environment. Unlike pure optical methods, for which imaging depth is limited to a few hundred micrometers by significant optical scattering, photoacoustic detection of vibrational absorption breaks through the optical diffusion limit by taking advantage of diffused photons and weak acoustic scattering. Key features of this method include both high scalability of imaging depth from a few millimeters to a few centimeters and chemical bond selectivity as a novel contrast mechanism for photoacoustic imaging. Its biomedical applications spans detection of white matter loss and regeneration, assessment of breast tumor margins, and diagnosis of vulnerable atherosclerotic plaques. This review provides an overview of the recent advances made in vibration-based photoacoustic imaging and various biomedical applications enabled by this new technology. |
| first_indexed | 2024-12-21T21:18:13Z |
| format | Article |
| id | doaj.art-7c1f30942bcc43b98456ecfe40e540c6 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-12-21T21:18:13Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-7c1f30942bcc43b98456ecfe40e540c62022-12-21T18:49:57ZengElsevierPhotoacoustics2213-59792016-03-0141112110.1016/j.pacs.2016.01.002Bond-selective photoacoustic imaging by converting molecular vibration into acoustic wavesJie Hui0Rui Li1Evan H. Phillips2Craig J. Goergen3Michael Sturek4Ji-Xin Cheng5Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USAWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USAWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USAWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USAWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USAWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USAThe quantized vibration of chemical bonds provides a way of detecting specific molecules in a complex tissue environment. Unlike pure optical methods, for which imaging depth is limited to a few hundred micrometers by significant optical scattering, photoacoustic detection of vibrational absorption breaks through the optical diffusion limit by taking advantage of diffused photons and weak acoustic scattering. Key features of this method include both high scalability of imaging depth from a few millimeters to a few centimeters and chemical bond selectivity as a novel contrast mechanism for photoacoustic imaging. Its biomedical applications spans detection of white matter loss and regeneration, assessment of breast tumor margins, and diagnosis of vulnerable atherosclerotic plaques. This review provides an overview of the recent advances made in vibration-based photoacoustic imaging and various biomedical applications enabled by this new technology.http://www.sciencedirect.com/science/article/pii/S2213597916300027Overtone absorptionPhotoacoustic microscopyPhotoacoustic tomographyIntravascular photoacousticLipidAtherosclerosisTumor margin |
| spellingShingle | Jie Hui Rui Li Evan H. Phillips Craig J. Goergen Michael Sturek Ji-Xin Cheng Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves Photoacoustics Overtone absorption Photoacoustic microscopy Photoacoustic tomography Intravascular photoacoustic Lipid Atherosclerosis Tumor margin |
| title | Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves |
| title_full | Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves |
| title_fullStr | Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves |
| title_full_unstemmed | Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves |
| title_short | Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves |
| title_sort | bond selective photoacoustic imaging by converting molecular vibration into acoustic waves |
| topic | Overtone absorption Photoacoustic microscopy Photoacoustic tomography Intravascular photoacoustic Lipid Atherosclerosis Tumor margin |
| url | http://www.sciencedirect.com/science/article/pii/S2213597916300027 |
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