Orexins in apoptosis: a dual regulatory role
The orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central and peripheral nervous systems. Orexins are rec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1336145/full |
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| author | Simona Cavalu Sameh Saber Rabab S. Hamad Rabab S. Hamad Mustafa Ahmed Abdel-Reheim Mustafa Ahmed Abdel-Reheim Elsayed A. Elmorsy Elsayed A. Elmorsy Mahmoud E. Youssef |
| author_facet | Simona Cavalu Sameh Saber Rabab S. Hamad Rabab S. Hamad Mustafa Ahmed Abdel-Reheim Mustafa Ahmed Abdel-Reheim Elsayed A. Elmorsy Elsayed A. Elmorsy Mahmoud E. Youssef |
| author_sort | Simona Cavalu |
| collection | DOAJ |
| description | The orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central and peripheral nervous systems. Orexins are recognized to regulate diverse functions, involving energy homeostasis, the sleep-wake cycle, stress responses, and reward-seeking behaviors. Additionally, it is suggested that orexin-A deficiency is linked to sleepiness and narcolepsy. The orexins bind to their respective receptors, the orexin receptor type 1 (OX1R) and type 2 (OX2R), and activate different signaling pathways, which results in the mediation of various physiological functions. Orexin receptors are widely expressed in different parts of the body, including the skin, muscles, lungs, and bone marrow. The expression levels of orexins and their receptors play a crucial role in apoptosis, which makes them a potential target for clinical treatment of various disorders. This article delves into the significance of orexins and orexin receptors in the process of apoptosis, highlighting their expression levels and their potential contributions to different diseases. The article offers an overview of the existing understanding of the orexin/receptor system and how it influences the regulation of apoptosis. |
| first_indexed | 2024-04-24T07:51:11Z |
| format | Article |
| id | doaj.art-7c2019435bfd485dbd9cbf27b26ff8d7 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-24T07:51:11Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-7c2019435bfd485dbd9cbf27b26ff8d72024-04-18T12:48:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-04-011810.3389/fncel.2024.13361451336145Orexins in apoptosis: a dual regulatory roleSimona Cavalu0Sameh Saber1Rabab S. Hamad2Rabab S. Hamad3Mustafa Ahmed Abdel-Reheim4Mustafa Ahmed Abdel-Reheim5Elsayed A. Elmorsy6Elsayed A. Elmorsy7Mahmoud E. Youssef8Faculty of Medicine and Pharmacy, University of Oradea, Oradea, RomaniaDepartment of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, EgyptBiological Sciences Department, College of Science, King Faisal University, Al Ahsa, Saudi ArabiaCentral Laboratory, Theodor Bilharz Research Institute, Giza, EgyptDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, EgyptDepartment of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraidah, Saudi ArabiaDepartment of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, EgyptThe orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central and peripheral nervous systems. Orexins are recognized to regulate diverse functions, involving energy homeostasis, the sleep-wake cycle, stress responses, and reward-seeking behaviors. Additionally, it is suggested that orexin-A deficiency is linked to sleepiness and narcolepsy. The orexins bind to their respective receptors, the orexin receptor type 1 (OX1R) and type 2 (OX2R), and activate different signaling pathways, which results in the mediation of various physiological functions. Orexin receptors are widely expressed in different parts of the body, including the skin, muscles, lungs, and bone marrow. The expression levels of orexins and their receptors play a crucial role in apoptosis, which makes them a potential target for clinical treatment of various disorders. This article delves into the significance of orexins and orexin receptors in the process of apoptosis, highlighting their expression levels and their potential contributions to different diseases. The article offers an overview of the existing understanding of the orexin/receptor system and how it influences the regulation of apoptosis.https://www.frontiersin.org/articles/10.3389/fncel.2024.1336145/fullorexinsapoptosisCNS disordersneuroprotectioncell signalingnew therapeutic target |
| spellingShingle | Simona Cavalu Sameh Saber Rabab S. Hamad Rabab S. Hamad Mustafa Ahmed Abdel-Reheim Mustafa Ahmed Abdel-Reheim Elsayed A. Elmorsy Elsayed A. Elmorsy Mahmoud E. Youssef Orexins in apoptosis: a dual regulatory role Frontiers in Cellular Neuroscience orexins apoptosis CNS disorders neuroprotection cell signaling new therapeutic target |
| title | Orexins in apoptosis: a dual regulatory role |
| title_full | Orexins in apoptosis: a dual regulatory role |
| title_fullStr | Orexins in apoptosis: a dual regulatory role |
| title_full_unstemmed | Orexins in apoptosis: a dual regulatory role |
| title_short | Orexins in apoptosis: a dual regulatory role |
| title_sort | orexins in apoptosis a dual regulatory role |
| topic | orexins apoptosis CNS disorders neuroprotection cell signaling new therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1336145/full |
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