Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications
Head and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that often lead to debilitating changes in appearance, speech, swallowing and respiratory function in patients. It is therefore critical to develop novel targeted treatment strategies that can effectively target mul...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oral Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2021.689482/full |
| _version_ | 1818608230190809088 |
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| author | Vui King Vincent-Chong Mukund Seshadri Mukund Seshadri |
| author_facet | Vui King Vincent-Chong Mukund Seshadri Mukund Seshadri |
| author_sort | Vui King Vincent-Chong |
| collection | DOAJ |
| description | Head and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that often lead to debilitating changes in appearance, speech, swallowing and respiratory function in patients. It is therefore critical to develop novel targeted treatment strategies that can effectively target multiple components within the tumor microenvironment. In this regard, there has been an increased recognition of the role of neural signaling networks as mediators of disease progression in HNSCC. Here, we summarize the current knowledge on the mechanisms of adrenergic signaling in HNSCC specifically focusing on neurovascular crosstalk and the potential of targeting the adrenergic-angiogenic axis through repurposing of FDA-approved drugs against HNSCC. |
| first_indexed | 2024-12-16T14:39:20Z |
| format | Article |
| id | doaj.art-7c216962a25b484e861262df616544d0 |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-12-16T14:39:20Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-7c216962a25b484e861262df616544d02022-12-21T22:28:00ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422021-06-01210.3389/froh.2021.689482689482Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic ImplicationsVui King Vincent-Chong0Mukund Seshadri1Mukund Seshadri2Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesCenter for Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesDepartment of Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesHead and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that often lead to debilitating changes in appearance, speech, swallowing and respiratory function in patients. It is therefore critical to develop novel targeted treatment strategies that can effectively target multiple components within the tumor microenvironment. In this regard, there has been an increased recognition of the role of neural signaling networks as mediators of disease progression in HNSCC. Here, we summarize the current knowledge on the mechanisms of adrenergic signaling in HNSCC specifically focusing on neurovascular crosstalk and the potential of targeting the adrenergic-angiogenic axis through repurposing of FDA-approved drugs against HNSCC.https://www.frontiersin.org/articles/10.3389/froh.2021.689482/fullHNSCCadrenergic signalingangiogenesisdrug repurposingpropranolol |
| spellingShingle | Vui King Vincent-Chong Mukund Seshadri Mukund Seshadri Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications Frontiers in Oral Health HNSCC adrenergic signaling angiogenesis drug repurposing propranolol |
| title | Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications |
| title_full | Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications |
| title_fullStr | Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications |
| title_full_unstemmed | Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications |
| title_short | Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications |
| title_sort | adrenergic angiogenic crosstalk in head and neck cancer mechanisms and therapeutic implications |
| topic | HNSCC adrenergic signaling angiogenesis drug repurposing propranolol |
| url | https://www.frontiersin.org/articles/10.3389/froh.2021.689482/full |
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