Recombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study

Recombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study

Abstract Background Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protection properties. Herein, we investigated whether rAT therapy has benefic...

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Bibliographic Details
Main Authors: Tomotaka Miura, Tomoki Okuda, Kodai Suzuki, Hideshi Okada, Hiroyuki Tomita, Chihiro Takada, Kosuke Mori, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Yohei Fukuda, Hirotsugu Fukuda, Ayane Nishio, Yuki Kawasaki, Ayumi Kuroda, Keiko Suzuki, Ryo Kamidani, Haruka Okamoto, Tetsuya Fukuta, Yuichiro Kitagawa, Takahito Miyake, Keita Nakane, Akio Suzuki, Takahiro Yoshida, Nobuyuki Tetsuka, Shozo Yoshida, Takuya Koie, Shinji Ogura
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:Intensive Care Medicine Experimental
Subjects:
Acute kidney injury
Rhabdomyolysis
Recombinant antithrombin
In vivo mice model
Novel treatment
Online Access:https://doi.org/10.1186/s40635-024-00594-y

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