4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase. PR3-ANCA binding to membrane-bound PR3 on neutrophils induce their auto-immune...

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Bibliographic Details
Main Authors: Jérôme Granel, Roxane Lemoine, Eric Morello, Yann Gallais, Julie Mariot, Marion Drapeau, Astrid Musnier, Anne Poupon, Martine Pugnière, Seda Seren, Dalila Nouar, Valérie Gouilleux-Gruart, Hervé Watier, Brice Korkmaz, Cyrille Hoarau
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
anti-neutrophil cytoplasmic antibodies
proteinase 3
granulomatosis with polyangiitis
epitope
human neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.573040/full

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