Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research
<i>Background and objectives:</i> Ample evidence indicates that oxidative stress, including complex lipid peroxidation processes, may play a significant role in the pathogenesis of colorectal cancer. The goal of this study was to evaluate selected oxidative stress markers in patients wit...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-01-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/56/2/47 |
| _version_ | 1797727567096053760 |
|---|---|
| author | Karolina Janion Elżbieta Szczepańska Ewa Nowakowska-Zajdel Joanna Strzelczyk Angelika Copija |
| author_facet | Karolina Janion Elżbieta Szczepańska Ewa Nowakowska-Zajdel Joanna Strzelczyk Angelika Copija |
| author_sort | Karolina Janion |
| collection | DOAJ |
| description | <i>Background and objectives:</i> Ample evidence indicates that oxidative stress, including complex lipid peroxidation processes, may play a significant role in the pathogenesis of colorectal cancer. The goal of this study was to evaluate selected oxidative stress markers in patients with colorectal cancer depending on some clinical features, with particular attention paid to the location of the primary tumor. <i>Materials and Methods:</i> The study was conducted on a group of 66 patients with colorectal cancer. The study consisted of two stages. The first stage involved the analysis of medical records; the second consisted of determining selected oxidative stress markers by measuring malondialdehyde as well as total oxidant and antioxidant status. <i>Results:</i> Of all patients, 43 (65.15%) had colon cancer, of whom 30 (69.77%) had a tumor on the left side and 13 (30.23%) had a tumor on the right side of the colon. Of all the patients, 23 (34.85%) had rectal cancer. The mean total oxidant and antioxidant status was 809.76 (SD ± 392.65) µmol/L and 253.19 (233.33−310.66) µmol/L, respectively. The mean malondialdehyde serum level was 2478.04 (SD ± 1397.05) ng/mL. The mean malondialdehyde serum concentration in patients with primary tumors located on the right side was higher in a statistically significant way compared with the remaining patients. <i>Conclusions:</i> It was demonstrated that the intensity of lipid peroxidation processes is correlated with the development of colorectal cancer, particularly on the right side. The results should be interpreted rather cautiously due to certain limitations of the study. |
| first_indexed | 2024-03-12T11:01:32Z |
| format | Article |
| id | doaj.art-7c23fafb8801435d9ed6545b35899ea8 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:01:32Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-7c23fafb8801435d9ed6545b35899ea82023-09-02T05:33:46ZengMDPI AGMedicina1010-660X2020-01-015624710.3390/medicina56020047medicina56020047Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary ResearchKarolina Janion0Elżbieta Szczepańska1Ewa Nowakowska-Zajdel2Joanna Strzelczyk3Angelika Copija4Department of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, School of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Human Nutrition, School of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, School of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Medical and Molecular Biology, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, School of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland<i>Background and objectives:</i> Ample evidence indicates that oxidative stress, including complex lipid peroxidation processes, may play a significant role in the pathogenesis of colorectal cancer. The goal of this study was to evaluate selected oxidative stress markers in patients with colorectal cancer depending on some clinical features, with particular attention paid to the location of the primary tumor. <i>Materials and Methods:</i> The study was conducted on a group of 66 patients with colorectal cancer. The study consisted of two stages. The first stage involved the analysis of medical records; the second consisted of determining selected oxidative stress markers by measuring malondialdehyde as well as total oxidant and antioxidant status. <i>Results:</i> Of all patients, 43 (65.15%) had colon cancer, of whom 30 (69.77%) had a tumor on the left side and 13 (30.23%) had a tumor on the right side of the colon. Of all the patients, 23 (34.85%) had rectal cancer. The mean total oxidant and antioxidant status was 809.76 (SD ± 392.65) µmol/L and 253.19 (233.33−310.66) µmol/L, respectively. The mean malondialdehyde serum level was 2478.04 (SD ± 1397.05) ng/mL. The mean malondialdehyde serum concentration in patients with primary tumors located on the right side was higher in a statistically significant way compared with the remaining patients. <i>Conclusions:</i> It was demonstrated that the intensity of lipid peroxidation processes is correlated with the development of colorectal cancer, particularly on the right side. The results should be interpreted rather cautiously due to certain limitations of the study.https://www.mdpi.com/1010-660X/56/2/47colorectal canceroxidative stresslipid peroxidationright/left sided tumor |
| spellingShingle | Karolina Janion Elżbieta Szczepańska Ewa Nowakowska-Zajdel Joanna Strzelczyk Angelika Copija Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research Medicina colorectal cancer oxidative stress lipid peroxidation right/left sided tumor |
| title | Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research |
| title_full | Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research |
| title_fullStr | Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research |
| title_full_unstemmed | Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research |
| title_short | Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research |
| title_sort | selected oxidative stress markers in colorectal cancer patients in relation to primary tumor location a preliminary research |
| topic | colorectal cancer oxidative stress lipid peroxidation right/left sided tumor |
| url | https://www.mdpi.com/1010-660X/56/2/47 |
| work_keys_str_mv | AT karolinajanion selectedoxidativestressmarkersincolorectalcancerpatientsinrelationtoprimarytumorlocationapreliminaryresearch AT elzbietaszczepanska selectedoxidativestressmarkersincolorectalcancerpatientsinrelationtoprimarytumorlocationapreliminaryresearch AT ewanowakowskazajdel selectedoxidativestressmarkersincolorectalcancerpatientsinrelationtoprimarytumorlocationapreliminaryresearch AT joannastrzelczyk selectedoxidativestressmarkersincolorectalcancerpatientsinrelationtoprimarytumorlocationapreliminaryresearch AT angelikacopija selectedoxidativestressmarkersincolorectalcancerpatientsinrelationtoprimarytumorlocationapreliminaryresearch |