Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles
Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar cycloaddition. The dipoles generated from hyd...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2021-06-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/6466 |
| _version_ | 1818356951097016320 |
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| author | Avula Sri Nivas Enugala Kalyan Rao |
| author_facet | Avula Sri Nivas Enugala Kalyan Rao |
| author_sort | Avula Sri Nivas |
| collection | DOAJ |
| description | Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar cycloaddition. The dipoles generated from hydrazine hydrochloride, hydroxylamine and guanidine hydrochloride were reacted with macrocyclic enone to give a new class of spiro aminopyrimidines, phenyl pyrazoles and isoxazoles grafted macrocycles in good yield. The structures of newly synthesized compounds were confirmed with IR, NMR and mass spectroscopy and evaluated for their anti cancer activity. |
| first_indexed | 2024-12-13T20:05:22Z |
| format | Article |
| id | doaj.art-7c245b71741345928d563e1f8bb88508 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-13T20:05:22Z |
| publishDate | 2021-06-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-7c245b71741345928d563e1f8bb885082022-12-21T23:33:02ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552021-06-0168240441310.17344/acsi.2020.6466963Synthesis and Anticancer Activity of Triazole Linked Macrocycles and HeterocyclesAvula Sri Nivas0Enugala Kalyan Rao1Lec in chemistryLec in chemistrySynthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar cycloaddition. The dipoles generated from hydrazine hydrochloride, hydroxylamine and guanidine hydrochloride were reacted with macrocyclic enone to give a new class of spiro aminopyrimidines, phenyl pyrazoles and isoxazoles grafted macrocycles in good yield. The structures of newly synthesized compounds were confirmed with IR, NMR and mass spectroscopy and evaluated for their anti cancer activity.https://journals.matheo.si/index.php/ACSi/article/view/6466triazolesclick reactioninternal aldol condensationmacrocyclicenonesanticanceractivity |
| spellingShingle | Avula Sri Nivas Enugala Kalyan Rao Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles Acta Chimica Slovenica triazoles click reaction internal aldol condensation macrocyclicenones anticanceractivity |
| title | Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles |
| title_full | Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles |
| title_fullStr | Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles |
| title_full_unstemmed | Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles |
| title_short | Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles |
| title_sort | synthesis and anticancer activity of triazole linked macrocycles and heterocycles |
| topic | triazoles click reaction internal aldol condensation macrocyclicenones anticanceractivity |
| url | https://journals.matheo.si/index.php/ACSi/article/view/6466 |
| work_keys_str_mv | AT avulasrinivas synthesisandanticanceractivityoftriazolelinkedmacrocyclesandheterocycles AT enugalakalyanrao synthesisandanticanceractivityoftriazolelinkedmacrocyclesandheterocycles |