Primary cutaneous B-cell lymphoma and chronic leg ulcers in a patient with type 2 diabetes
The incidences of type 2 diabetes mellitus and many cancers are rapidly increasing worldwide. Diabetes is a strong risk factor for some cancers (including lymphomas) and is also associated with adverse cancer outcomes. After gastrointestinal tract, the skin is the second most frequent extranodal s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2017-05-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0032 |
| Summary: | The incidences of type 2 diabetes mellitus and many cancers are rapidly increasing worldwide. Diabetes is a strong risk
factor for some cancers (including lymphomas) and is also associated with adverse cancer outcomes. After gastrointestinal
tract, the skin is the second most frequent extranodal site involved by non-Hodgkin lymphomas and the cutaneous B-cell
lymphomas (CBCLs) range from 25% to 30% of all primary cutaneous lymphomas. The primary cutaneous diffuse large
B-cell lymphoma (PCDLBCL) is an aggressive lymphoma with a poor prognosis, representing roughly 20% of all primary
CBCLs. Classically, the cutaneous manifestation of this lymphoma is a red or violaceous tumors arising on a leg. To date,
despite the large body of evidence suggesting that diabetes is strongly associated with an increased risk of some cancers,
very little information is available regarding a possible association between type 2 diabetes and primary cutaneous
diffuse large B-cell lymphoma. In this report, we will present the case of a white adult patient with type 2 diabetes with
chronic leg ulcers complicated by a primary cutaneous diffuse large B-cell lymphoma. |
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| ISSN: | 2052-0573 2052-0573 |