Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention
Abstract We developed the Navigate intervention to improve survival among vulnerable lung cancer patients. In this intervention-only study, we examined feasibility in terms of recruitment, retention, attendance, adherence, and acceptability to specify adjustments to study procedures and intervention...
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Nature Portfolio
2023-12-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-50161-w |
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author | Rikke Langballe Lukas Svendsen Erik Jakobsen Susanne Oksbjerg Dalton Randi Valbjørn Karlsen Maria Iachina Karen M. Freund Amy Leclair Lars Bo Jørgensen Søren T. Skou Jeanette Haar Ehlers Rikke Torenholt Mads Nordahl Svendsen Pernille Envold Bidstrup |
author_facet | Rikke Langballe Lukas Svendsen Erik Jakobsen Susanne Oksbjerg Dalton Randi Valbjørn Karlsen Maria Iachina Karen M. Freund Amy Leclair Lars Bo Jørgensen Søren T. Skou Jeanette Haar Ehlers Rikke Torenholt Mads Nordahl Svendsen Pernille Envold Bidstrup |
author_sort | Rikke Langballe |
collection | DOAJ |
description | Abstract We developed the Navigate intervention to improve survival among vulnerable lung cancer patients. In this intervention-only study, we examined feasibility in terms of recruitment, retention, attendance, adherence, and acceptability to specify adjustments to study procedures and intervention components prior to a randomized trial. The Navigate intervention includes nurse navigation, patient-reported outcomes, and physical exercise. Patients ≥ 18 years old, diagnosed with non-small cell lung cancer at any stage, with performance status ≤ 2, eligible for cancer treatment and vulnerable according to a screening instrument were included. The recruitment goal of eligible patients was 40% while the retention goal was 85%. The predefined cut-offs for sufficient attendance and adherence were ≥ 75%. Acceptability was evaluated by semi-structured interviews with participants, nurse navigators, and physiotherapists. Seventeen (56%) out of 30 screened patients were considered vulnerable and eligible for the study, 14 (82%) accepted participation, and 3 (21%) were subsequently excluded due to ineligibility, leaving 11 patients. Four patients dropped out (36%) and four patients died (36%) during follow-up and 3 (27%) were retained. All 11 patients participated in nurse sessions (mean 16, range 1–36) with 88% attendance and dialogue tools being applied in 68% of sessions. Ninety-one percent of patients responded to PROs (mean of 9 PROs, range 1–24) with 76% of the PRO questionnaires used (attendance) and 100% adherence (completion of all questions in PRO questionnaires), and 55% participated in exercise sessions with 58% attendance and 85% adherence. We identified important barriers primarily related to transportation, but overall acceptability was high. The Navigate intervention was feasible with high participation, acceptability and satisfactory adherence. Retention and exercise attendance were low, which resulted in adjustments. Trial registration: The feasibility study was initiated prior to the multicenter randomized controlled trial registered by ClinicalTrials.gov (number: NCT05053997; date 23/09/2021). |
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format | Article |
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institution | Directory Open Access Journal |
issn | 2045-2322 |
language | English |
last_indexed | 2024-03-08T19:48:25Z |
publishDate | 2023-12-01 |
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spelling | doaj.art-7c2603baf2e741ac9236356b437c852b2023-12-24T12:13:48ZengNature PortfolioScientific Reports2045-23222023-12-0113111310.1038/s41598-023-50161-wNurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE interventionRikke Langballe0Lukas Svendsen1Erik Jakobsen2Susanne Oksbjerg Dalton3Randi Valbjørn Karlsen4Maria Iachina5Karen M. Freund6Amy Leclair7Lars Bo Jørgensen8Søren T. Skou9Jeanette Haar Ehlers10Rikke Torenholt11Mads Nordahl Svendsen12Pernille Envold Bidstrup13Psychological Aspects of Cancer, Cancer Survivorship, Danish Cancer InstitutePsychological Aspects of Cancer, Cancer Survivorship, Danish Cancer InstituteDepartment of Thoracic Surgery, Odense University HospitalCancer Survivorship, Danish Cancer InstitutePsychological Aspects of Cancer, Cancer Survivorship, Danish Cancer InstituteCenter for Clinical Epidemiology and Research Unit of Clinical Epidemiology, Odense University HospitalDepartment of Medicine, Tufts Medical Center, Tufts University School of MedicineDepartment of Medicine, Tufts Medical Center, Tufts University School of MedicineThe Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted HospitalsThe Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted HospitalsDepartment of Clinical Oncology and Palliative Care, Zealand University HospitalPsychological Aspects of Cancer, Cancer Survivorship, Danish Cancer InstituteDepartment of Clinical Oncology and Palliative Care, Zealand University HospitalPsychological Aspects of Cancer, Cancer Survivorship, Danish Cancer InstituteAbstract We developed the Navigate intervention to improve survival among vulnerable lung cancer patients. In this intervention-only study, we examined feasibility in terms of recruitment, retention, attendance, adherence, and acceptability to specify adjustments to study procedures and intervention components prior to a randomized trial. The Navigate intervention includes nurse navigation, patient-reported outcomes, and physical exercise. Patients ≥ 18 years old, diagnosed with non-small cell lung cancer at any stage, with performance status ≤ 2, eligible for cancer treatment and vulnerable according to a screening instrument were included. The recruitment goal of eligible patients was 40% while the retention goal was 85%. The predefined cut-offs for sufficient attendance and adherence were ≥ 75%. Acceptability was evaluated by semi-structured interviews with participants, nurse navigators, and physiotherapists. Seventeen (56%) out of 30 screened patients were considered vulnerable and eligible for the study, 14 (82%) accepted participation, and 3 (21%) were subsequently excluded due to ineligibility, leaving 11 patients. Four patients dropped out (36%) and four patients died (36%) during follow-up and 3 (27%) were retained. All 11 patients participated in nurse sessions (mean 16, range 1–36) with 88% attendance and dialogue tools being applied in 68% of sessions. Ninety-one percent of patients responded to PROs (mean of 9 PROs, range 1–24) with 76% of the PRO questionnaires used (attendance) and 100% adherence (completion of all questions in PRO questionnaires), and 55% participated in exercise sessions with 58% attendance and 85% adherence. We identified important barriers primarily related to transportation, but overall acceptability was high. The Navigate intervention was feasible with high participation, acceptability and satisfactory adherence. Retention and exercise attendance were low, which resulted in adjustments. Trial registration: The feasibility study was initiated prior to the multicenter randomized controlled trial registered by ClinicalTrials.gov (number: NCT05053997; date 23/09/2021).https://doi.org/10.1038/s41598-023-50161-w |
spellingShingle | Rikke Langballe Lukas Svendsen Erik Jakobsen Susanne Oksbjerg Dalton Randi Valbjørn Karlsen Maria Iachina Karen M. Freund Amy Leclair Lars Bo Jørgensen Søren T. Skou Jeanette Haar Ehlers Rikke Torenholt Mads Nordahl Svendsen Pernille Envold Bidstrup Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention Scientific Reports |
title | Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention |
title_full | Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention |
title_fullStr | Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention |
title_full_unstemmed | Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention |
title_short | Nurse navigation, symptom monitoring and exercise in vulnerable patients with lung cancer: feasibility of the NAVIGATE intervention |
title_sort | nurse navigation symptom monitoring and exercise in vulnerable patients with lung cancer feasibility of the navigate intervention |
url | https://doi.org/10.1038/s41598-023-50161-w |
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