Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer
Abstract The purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01086-9 |
| _version_ | 1819001462908256256 |
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| author | Jae-Hoon Lee Soyoung Kim Hye Sun Lee Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang |
| author_facet | Jae-Hoon Lee Soyoung Kim Hye Sun Lee Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang |
| author_sort | Jae-Hoon Lee |
| collection | DOAJ |
| description | Abstract The purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients. |
| first_indexed | 2024-12-20T22:49:36Z |
| format | Article |
| id | doaj.art-7c271fe69f5b408babb18d68b8f6a0dd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T22:49:36Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7c271fe69f5b408babb18d68b8f6a0dd2022-12-21T19:24:17ZengNature PortfolioScientific Reports2045-23222021-11-0111111110.1038/s41598-021-01086-9Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancerJae-Hoon Lee0Soyoung Kim1Hye Sun Lee2Eun Jung Park3Seung Hyuk Baik4Tae Joo Jeon5Kang Young Lee6Young Hoon Ryu7Jeonghyun Kang8Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineBiostatistics Collaboration Unit, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract The purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.https://doi.org/10.1038/s41598-021-01086-9 |
| spellingShingle | Jae-Hoon Lee Soyoung Kim Hye Sun Lee Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer Scientific Reports |
| title | Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer |
| title_full | Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer |
| title_fullStr | Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer |
| title_full_unstemmed | Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer |
| title_short | Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer |
| title_sort | different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer |
| url | https://doi.org/10.1038/s41598-021-01086-9 |
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