The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans
Abstract Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular attention is paid to endocannabinoid system (eCB) and its main receptors...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Laboratory Animal Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42826-022-00116-5 |
| _version_ | 1818988080553525248 |
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| author | Ricardo Lacava Bailone Hirla Costa Silva Fukushima Luis Kluwe de Aguiar Ricardo Carneiro Borra |
| author_facet | Ricardo Lacava Bailone Hirla Costa Silva Fukushima Luis Kluwe de Aguiar Ricardo Carneiro Borra |
| author_sort | Ricardo Lacava Bailone |
| collection | DOAJ |
| description | Abstract Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular attention is paid to endocannabinoid system (eCB) and its main receptors (CB1 and CB2). The zebrafish model is a promising one for the study of cannabinoids because of the many similarities to the human system. Despite the recent advances on the eCB system, there is still the need to elucidate some of the interactions and, thus, the zebrafish model can be used for that purpose as it respects the 3Rs concept and reduced time and costs. In view of the relevance of cannabinoids in the treatment and prevention of diseases, as well as the importance of the zebrafish animal model in elucidating the biological effects of new drugs, the aim of this study was to bring to light information on the use of the zebrafish animal model in testing C. sativa-based medicines. |
| first_indexed | 2024-12-20T19:16:54Z |
| format | Article |
| id | doaj.art-7c27d7ec18b54ac491f7181e8ec25a51 |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-12-20T19:16:54Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-7c27d7ec18b54ac491f7181e8ec25a512022-12-21T19:29:05ZengBMCLaboratory Animal Research2233-76602022-02-0138111210.1186/s42826-022-00116-5The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humansRicardo Lacava Bailone0Hirla Costa Silva Fukushima1Luis Kluwe de Aguiar2Ricardo Carneiro Borra3Department of Genetic and Evolution, Federal University of São CarlosCentre of Biological and Health Sciences, Federal University of Sao CarlosDepartment of Food, Land and Agribusiness Management, Harper Adams UniversityDepartment of Genetic and Evolution, Federal University of São CarlosAbstract Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular attention is paid to endocannabinoid system (eCB) and its main receptors (CB1 and CB2). The zebrafish model is a promising one for the study of cannabinoids because of the many similarities to the human system. Despite the recent advances on the eCB system, there is still the need to elucidate some of the interactions and, thus, the zebrafish model can be used for that purpose as it respects the 3Rs concept and reduced time and costs. In view of the relevance of cannabinoids in the treatment and prevention of diseases, as well as the importance of the zebrafish animal model in elucidating the biological effects of new drugs, the aim of this study was to bring to light information on the use of the zebrafish animal model in testing C. sativa-based medicines.https://doi.org/10.1186/s42826-022-00116-53R∆9-tetrahydrocannabinolAnimal model researchCannabidiolCB1CB2 |
| spellingShingle | Ricardo Lacava Bailone Hirla Costa Silva Fukushima Luis Kluwe de Aguiar Ricardo Carneiro Borra The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans Laboratory Animal Research 3R ∆9-tetrahydrocannabinol Animal model research Cannabidiol CB1 CB2 |
| title | The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans |
| title_full | The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans |
| title_fullStr | The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans |
| title_full_unstemmed | The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans |
| title_short | The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans |
| title_sort | endocannabinoid system in zebrafish and its potential to study the effects of cannabis in humans |
| topic | 3R ∆9-tetrahydrocannabinol Animal model research Cannabidiol CB1 CB2 |
| url | https://doi.org/10.1186/s42826-022-00116-5 |
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