Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors
For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S193652332400007X |
| _version_ | 1797324342035480576 |
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| author | Maria Diaz Sofia Chudsky Elena Pentsova Alexandra M. Miller |
| author_facet | Maria Diaz Sofia Chudsky Elena Pentsova Alexandra M. Miller |
| author_sort | Maria Diaz |
| collection | DOAJ |
| description | For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). CTCs have been employed mostly as a diagnostic tool for leptomeningeal metastases in epithelial tumors, although they may also have value in the prognostication and monitoring of this disease. The ctDNA technology has been studied in a variety of primary and metastatic brain and spinal cord tumors, where it can be used for diagnosis and molecular classification, with some work suggesting that it may also be useful for longitudinal tracking of tumor evolution or as a marker of residual disease. This review summarizes recent publications on the use of these two tests in CSF, focusing on their established and potential clinical applications. |
| first_indexed | 2024-03-08T05:54:45Z |
| format | Article |
| id | doaj.art-7c291ae422f443cead81496da3273ec4 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-03-08T05:54:45Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-7c291ae422f443cead81496da3273ec42024-02-05T04:31:39ZengElsevierTranslational Oncology1936-52332024-03-0141101881Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumorsMaria Diaz0Sofia Chudsky1Elena Pentsova2Alexandra M. Miller3Department of Neurology, Division of Neuro-Oncology, Columbia University Irving Medical Center, New York, NY, USAOffice of Professional Development, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Hunter College, New York, NY, USADepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Corresponding author at: Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). CTCs have been employed mostly as a diagnostic tool for leptomeningeal metastases in epithelial tumors, although they may also have value in the prognostication and monitoring of this disease. The ctDNA technology has been studied in a variety of primary and metastatic brain and spinal cord tumors, where it can be used for diagnosis and molecular classification, with some work suggesting that it may also be useful for longitudinal tracking of tumor evolution or as a marker of residual disease. This review summarizes recent publications on the use of these two tests in CSF, focusing on their established and potential clinical applications.http://www.sciencedirect.com/science/article/pii/S193652332400007XLiquid biopsyCerebrospinal fluidTumor biomarkersCirculating tumor cellsCell-free DNACirculating tumor DNA |
| spellingShingle | Maria Diaz Sofia Chudsky Elena Pentsova Alexandra M. Miller Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors Translational Oncology Liquid biopsy Cerebrospinal fluid Tumor biomarkers Circulating tumor cells Cell-free DNA Circulating tumor DNA |
| title | Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| title_full | Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| title_fullStr | Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| title_full_unstemmed | Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| title_short | Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| title_sort | clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| topic | Liquid biopsy Cerebrospinal fluid Tumor biomarkers Circulating tumor cells Cell-free DNA Circulating tumor DNA |
| url | http://www.sciencedirect.com/science/article/pii/S193652332400007X |
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