How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review
The off-label use of second-generation antihistamines, used outside of the formal indications authorized by regulatory authorities, in different age groups, doses or in special populations, is very common for many allergic, autoimmune and dermatological diseases. The off-label use of rupatadine (a s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BioExcel Publishing Ltd
2024-01-01
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| Series: | Drugs in Context |
| Subjects: | |
| Online Access: | https://www.drugsincontext.com/how-to-handle-off-label-prescriptions-of-rupatadine-a-second-generation-antihistamine-and-paf-antagonist-a-review/ |
| _version_ | 1797352235026350080 |
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| author | Iñaki Izquierdo Laia Casas Susana Cabrera Alberto Fernandez |
| author_facet | Iñaki Izquierdo Laia Casas Susana Cabrera Alberto Fernandez |
| author_sort | Iñaki Izquierdo |
| collection | DOAJ |
| description | The off-label use of second-generation antihistamines, used outside of the formal indications authorized by regulatory authorities, in different age groups, doses or in special populations, is very common for many allergic, autoimmune and dermatological diseases. The off-label use of rupatadine (a second-generation antihistamine with PAF antagonist activity) in these conditions is reviewed here, including in combination with immunotherapy in the treatment of food allergy or allergic rhinitis, at high doses in chronic urticaria, and with prescriptions of less common but challenging conditions such as skin pruritus or mast cell activation disorders like mastocytosis. Rupatadine use is reviewed herein to confirm if its off-label management is supported by well-designed clinical trials or by published real-world cases. This review will contribute to increasing compliance and achieving better results in clinical practice. Off-label use of rupatadine should be left to the discretion of the prescribing healthcare professional after careful clinical evaluation. |
| first_indexed | 2024-03-08T13:12:20Z |
| format | Article |
| id | doaj.art-7c292e323ad043fa9ace1a95ba706be7 |
| institution | Directory Open Access Journal |
| issn | 1740-4398 |
| language | English |
| last_indexed | 2024-03-08T13:12:20Z |
| publishDate | 2024-01-01 |
| publisher | BioExcel Publishing Ltd |
| record_format | Article |
| series | Drugs in Context |
| spelling | doaj.art-7c292e323ad043fa9ace1a95ba706be72024-01-18T11:09:41ZengBioExcel Publishing LtdDrugs in Context1740-43982024-01-011311010.7573/dic.2023-9-5How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a reviewIñaki IzquierdoLaia CasasSusana CabreraAlberto FernandezThe off-label use of second-generation antihistamines, used outside of the formal indications authorized by regulatory authorities, in different age groups, doses or in special populations, is very common for many allergic, autoimmune and dermatological diseases. The off-label use of rupatadine (a second-generation antihistamine with PAF antagonist activity) in these conditions is reviewed here, including in combination with immunotherapy in the treatment of food allergy or allergic rhinitis, at high doses in chronic urticaria, and with prescriptions of less common but challenging conditions such as skin pruritus or mast cell activation disorders like mastocytosis. Rupatadine use is reviewed herein to confirm if its off-label management is supported by well-designed clinical trials or by published real-world cases. This review will contribute to increasing compliance and achieving better results in clinical practice. Off-label use of rupatadine should be left to the discretion of the prescribing healthcare professional after careful clinical evaluation.https://www.drugsincontext.com/how-to-handle-off-label-prescriptions-of-rupatadine-a-second-generation-antihistamine-and-paf-antagonist-a-review/allergic rhinitisantihistaminechronic spontaneous urticariamast cell activation disordersoff-label useplatelet-activating factorpruritusrupatadine |
| spellingShingle | Iñaki Izquierdo Laia Casas Susana Cabrera Alberto Fernandez How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review Drugs in Context allergic rhinitis antihistamine chronic spontaneous urticaria mast cell activation disorders off-label use platelet-activating factor pruritus rupatadine |
| title | How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review |
| title_full | How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review |
| title_fullStr | How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review |
| title_full_unstemmed | How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review |
| title_short | How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review |
| title_sort | how to handle off label prescriptions of rupatadine a second generation antihistamine and paf antagonist a review |
| topic | allergic rhinitis antihistamine chronic spontaneous urticaria mast cell activation disorders off-label use platelet-activating factor pruritus rupatadine |
| url | https://www.drugsincontext.com/how-to-handle-off-label-prescriptions-of-rupatadine-a-second-generation-antihistamine-and-paf-antagonist-a-review/ |
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