Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study
Liver fibrosis scores, indicative of hepatic scarring, have recently been linked to coronary artery disease (CAD). We investigated the association between CAD and the fibrosis-4 index (FIB-4I) in patients who underwent coronary computed tomography angiography (CCTA). This study included 1244 patient...
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MDPI AG
2023-07-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/7/301 |
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| author | Tetsuo Hirata Yuhei Shiga Kohei Tashiro Sara Higashi Tetsuro Tachibana Yuto Kawahira Yasunori Suematsu Takashi Kuwano Makoto Sugihara Shin-ichiro Miura |
| author_facet | Tetsuo Hirata Yuhei Shiga Kohei Tashiro Sara Higashi Tetsuro Tachibana Yuto Kawahira Yasunori Suematsu Takashi Kuwano Makoto Sugihara Shin-ichiro Miura |
| author_sort | Tetsuo Hirata |
| collection | DOAJ |
| description | Liver fibrosis scores, indicative of hepatic scarring, have recently been linked to coronary artery disease (CAD). We investigated the association between CAD and the fibrosis-4 index (FIB-4I) in patients who underwent coronary computed tomography angiography (CCTA). This study included 1244 patients who were clinically suspected of having CAD. The presence or absence of CAD was the primary endpoint. FIB-4I was higher in the CAD group than in the non-CAD group (1.95 ± 1.21 versus [vs.] 1.65 ± 1.22, <i>p</i> < 0.001). FIB-4I was also higher in the hypertension (HTN) group than in the non-HTN group (1.90 ± 1.32 vs. 1.60 ± 0.98, <i>p</i> < 0.001). In all patients, high FIB-4I (≥2.67) was a predictor of presence of CAD (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.30–2.83, <i>p</i> = 0.001), and low FIB-4I (≤1.29) was proven to be a predictor of absence of CAD (OR: 0.65, 95% CI: 0.48–0.88, <i>p</i> = 0.006). In the HTN group, high and low FIB-4I levels, were found to be predictors for CAD (OR: 2.01, 95% CI: 1.26–3.21, <i>p</i> < 0.001 and OR: 0.65, 95% CI: 0.45–0.94, <i>p</i> < 0.022, respectively), in particular. FIB-4I may serve as a diagnostic indicator of the presence or absence of CAD in hypertensive patients undergoing CCTA. |
| first_indexed | 2024-03-11T00:58:46Z |
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| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T00:58:46Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
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| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-7c2a3e5772d14c25a834aa72fc5710da2023-11-18T19:50:20ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-07-0110730110.3390/jcdd10070301Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional StudyTetsuo Hirata0Yuhei Shiga1Kohei Tashiro2Sara Higashi3Tetsuro Tachibana4Yuto Kawahira5Yasunori Suematsu6Takashi Kuwano7Makoto Sugihara8Shin-ichiro Miura9Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanLiver fibrosis scores, indicative of hepatic scarring, have recently been linked to coronary artery disease (CAD). We investigated the association between CAD and the fibrosis-4 index (FIB-4I) in patients who underwent coronary computed tomography angiography (CCTA). This study included 1244 patients who were clinically suspected of having CAD. The presence or absence of CAD was the primary endpoint. FIB-4I was higher in the CAD group than in the non-CAD group (1.95 ± 1.21 versus [vs.] 1.65 ± 1.22, <i>p</i> < 0.001). FIB-4I was also higher in the hypertension (HTN) group than in the non-HTN group (1.90 ± 1.32 vs. 1.60 ± 0.98, <i>p</i> < 0.001). In all patients, high FIB-4I (≥2.67) was a predictor of presence of CAD (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.30–2.83, <i>p</i> = 0.001), and low FIB-4I (≤1.29) was proven to be a predictor of absence of CAD (OR: 0.65, 95% CI: 0.48–0.88, <i>p</i> = 0.006). In the HTN group, high and low FIB-4I levels, were found to be predictors for CAD (OR: 2.01, 95% CI: 1.26–3.21, <i>p</i> < 0.001 and OR: 0.65, 95% CI: 0.45–0.94, <i>p</i> < 0.022, respectively), in particular. FIB-4I may serve as a diagnostic indicator of the presence or absence of CAD in hypertensive patients undergoing CCTA.https://www.mdpi.com/2308-3425/10/7/301coronary artery diseasefibrosis-4 indexhypertensioncoronary computed tomography angiography |
| spellingShingle | Tetsuo Hirata Yuhei Shiga Kohei Tashiro Sara Higashi Tetsuro Tachibana Yuto Kawahira Yasunori Suematsu Takashi Kuwano Makoto Sugihara Shin-ichiro Miura Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study Journal of Cardiovascular Development and Disease coronary artery disease fibrosis-4 index hypertension coronary computed tomography angiography |
| title | Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study |
| title_full | Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study |
| title_fullStr | Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study |
| title_full_unstemmed | Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study |
| title_short | Investigating the Association between Coronary Artery Disease and the Liver Fibrosis-4 Index in Patients Who Underwent Coronary Computed Tomography Angiography: A Cross-Sectional Study |
| title_sort | investigating the association between coronary artery disease and the liver fibrosis 4 index in patients who underwent coronary computed tomography angiography a cross sectional study |
| topic | coronary artery disease fibrosis-4 index hypertension coronary computed tomography angiography |
| url | https://www.mdpi.com/2308-3425/10/7/301 |
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