Evaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosis

Evaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosis

Abstract Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome, which is characterized by podocyte injury. Given that the pathophysiology of nondiabetic glomerulosclerosis is poorly understood and targeted therapies to prevent glomerular disease are lacking, we decided...

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Bibliographic Details
Main Authors:	Guilherme Lopes-Gonçalves, Juliana Martins Costa-Pessoa, Ruan Pimenta, Ana Flavia Tostes, Eloisa Martins da Silva, Felipe Lourenço Ledesma, Denise Maria Avancini Costa Malheiros, Roberto Zatz, Karina Thieme, Niels Olsen Saraiva Câmara, Maria Oliveira-Souza
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-12-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-49861-0

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