Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature
Osteoporosis is a chronic disease requiring long-term, sometimes lifelong, management. With the aging population, the prevalence of osteoporosis is increasing, and with it so is the risk of hip fracture and subsequent poor quality of life and higher mortality. Current therapies for osteoporosis have...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.594247/full |
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| author | Xudong Xie Yuan Xiong Adriana C. Panayi Liangcong Hu Wu Zhou Hang Xue Ze Lin Lang Chen Chenchen Yan Bobin Mi Guohui Liu |
| author_facet | Xudong Xie Yuan Xiong Adriana C. Panayi Liangcong Hu Wu Zhou Hang Xue Ze Lin Lang Chen Chenchen Yan Bobin Mi Guohui Liu |
| author_sort | Xudong Xie |
| collection | DOAJ |
| description | Osteoporosis is a chronic disease requiring long-term, sometimes lifelong, management. With the aging population, the prevalence of osteoporosis is increasing, and with it so is the risk of hip fracture and subsequent poor quality of life and higher mortality. Current therapies for osteoporosis have various significant side effects limiting patient compliance and use. Recent evidence has demonstrated the significant role of exosomes in osteoporosis both in vivo and in vitro. In this review, we summarize the pathogenesis of senile osteoporosis, highlight the properties and advantages of exosomes, and explore the recent literature on the use of exosomes in osteogenesis regulation. This is a very helpful review as several exosomes-based therapeutics have recently entered clinical trials for non-skeletal applications, such as pancreatic cancer, renal transplantation, and therefore it is urgent for bone researchers to explore whether exosomes can become the next class of orthobiologics for the treatment of osteoporosis. |
| first_indexed | 2024-12-23T04:58:34Z |
| format | Article |
| id | doaj.art-7c2e9c5ef4514f20a223cdb8663d1cd8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-23T04:58:34Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-7c2e9c5ef4514f20a223cdb8663d1cd82022-12-21T17:59:17ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-10-01810.3389/fbioe.2020.594247594247Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the LiteratureXudong Xie0Yuan Xiong1Adriana C. Panayi2Liangcong Hu3Wu Zhou4Hang Xue5Ze Lin6Lang Chen7Chenchen Yan8Bobin Mi9Guohui Liu10Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaOsteoporosis is a chronic disease requiring long-term, sometimes lifelong, management. With the aging population, the prevalence of osteoporosis is increasing, and with it so is the risk of hip fracture and subsequent poor quality of life and higher mortality. Current therapies for osteoporosis have various significant side effects limiting patient compliance and use. Recent evidence has demonstrated the significant role of exosomes in osteoporosis both in vivo and in vitro. In this review, we summarize the pathogenesis of senile osteoporosis, highlight the properties and advantages of exosomes, and explore the recent literature on the use of exosomes in osteogenesis regulation. This is a very helpful review as several exosomes-based therapeutics have recently entered clinical trials for non-skeletal applications, such as pancreatic cancer, renal transplantation, and therefore it is urgent for bone researchers to explore whether exosomes can become the next class of orthobiologics for the treatment of osteoporosis.https://www.frontiersin.org/articles/10.3389/fbioe.2020.594247/fullosteoporosisexosomesmesenchymal stem cells (MSCs)osteoblastsosteoclasts |
| spellingShingle | Xudong Xie Yuan Xiong Adriana C. Panayi Liangcong Hu Wu Zhou Hang Xue Ze Lin Lang Chen Chenchen Yan Bobin Mi Guohui Liu Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature Frontiers in Bioengineering and Biotechnology osteoporosis exosomes mesenchymal stem cells (MSCs) osteoblasts osteoclasts |
| title | Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature |
| title_full | Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature |
| title_fullStr | Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature |
| title_full_unstemmed | Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature |
| title_short | Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature |
| title_sort | exosomes as a novel approach to reverse osteoporosis a review of the literature |
| topic | osteoporosis exosomes mesenchymal stem cells (MSCs) osteoblasts osteoclasts |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.594247/full |
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